1el3

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[[Image:1el3.gif|left|200px]]
[[Image:1el3.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1el3 |SIZE=350|CAPTION= <scene name='initialview01'>1el3</scene>, resolution 1.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1el3", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=I84:[2,6-DIMETHYL-4-(2-O-TOLYL-ACETYLAMINO)-BENZENESULFONYL]-GLYCINE'>I84</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1el3| PDB=1el3 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1el3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1el3 OCA], [http://www.ebi.ac.uk/pdbsum/1el3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1el3 RCSB]</span>
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}}
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'''HUMAN ALDOSE REDUCTASE COMPLEXED WITH IDD384 INHIBITOR'''
'''HUMAN ALDOSE REDUCTASE COMPLEXED WITH IDD384 INHIBITOR'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Podjarny, A.]]
[[Category: Podjarny, A.]]
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[[Category: aldose reductase]]
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[[Category: Aldose reductase]]
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[[Category: diabetes]]
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[[Category: Diabetes]]
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[[Category: inhibition]]
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[[Category: Inhibition]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:14:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:04:46 2008''
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Revision as of 12:14, 2 May 2008

Image:1el3.gif

Template:STRUCTURE 1el3

HUMAN ALDOSE REDUCTASE COMPLEXED WITH IDD384 INHIBITOR


Overview

The crystallographic structure of the complex between human aldose reductase (AR2) and one of its inhibitors, IDD384, has been solved at 1.7 A resolution from crystals obtained at pH 5.0. This structure shows that the binding of the inhibitor's hydrophilic head to the catalytic residues Tyr48 and His110 differs from that found previously with porcine AR2. The difference is attributed to a change in the protonation state of the inhibitor (pK(a) = 4.52) when soaked with crystals of human (at pH 5.0) or pig lens AR2 (at pH 6.2). This work demonstrates how strongly the detailed binding of the inhibitor's polar head depends on its protonation state.

About this Structure

1EL3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of human aldose reductase bound to the inhibitor IDD384., Calderone V, Chevrier B, Van Zandt M, Lamour V, Howard E, Poterszman A, Barth P, Mitschler A, Lu J, Dvornik DM, Klebe G, Kraemer O, Moorman AR, Moras D, Podjarny A, Acta Crystallogr D Biol Crystallogr. 2000 May;56(Pt 5):536-40. PMID:10771421 Page seeded by OCA on Fri May 2 15:14:00 2008

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OCA

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