1elq

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[[Image:1elq.gif|left|200px]]
[[Image:1elq.gif|left|200px]]
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{{Structure
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|PDB= 1elq |SIZE=350|CAPTION= <scene name='initialview01'>1elq</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1elq", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5&#39;-PHOSPHATE'>PLP</scene>
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{{STRUCTURE_1elq| PDB=1elq | SCENE= }}
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|RELATEDENTRY=[[1elu|1ELU]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1elq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1elq OCA], [http://www.ebi.ac.uk/pdbsum/1elq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1elq RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE CYSTINE C-S LYASE C-DES'''
'''CRYSTAL STRUCTURE OF THE CYSTINE C-S LYASE C-DES'''
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[[Category: Kessler, D.]]
[[Category: Kessler, D.]]
[[Category: Steegborn, C.]]
[[Category: Steegborn, C.]]
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[[Category: fes cluster biosynthesis]]
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[[Category: Fes cluster biosynthesis]]
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[[Category: nif]]
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[[Category: Nif]]
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[[Category: pyridoxal 5'-phosphate]]
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[[Category: Pyridoxal 5'-phosphate]]
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[[Category: thiocysteine]]
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[[Category: Thiocysteine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:05:12 2008''
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Revision as of 12:15, 2 May 2008

Template:STRUCTURE 1elq

CRYSTAL STRUCTURE OF THE CYSTINE C-S LYASE C-DES


Overview

FeS clusters are versatile cofactors of a variety of proteins, but the mechanisms of their biosynthesis are still unknown. The cystine C-S lyase from Synechocystis has been identified as a participant in ferredoxin FeS cluster formation. Herein, we report on the crystal structure of the lyase and of a complex with the reaction products of cystine cleavage at 1.8- and 1.55-A resolution, respectively. The sulfur-containing product was unequivocally identified as cysteine persulfide. The reactive persulfide group is fixed by a hydrogen bond to His-114 in the center of a hydrophobic pocket and is thereby shielded from the solvent. Binding and stabilization of the cysteine persulfide represent an alternative to the generation of a protein-bound persulfide by NifS-like proteins and point to the general importance of persulfidic compounds for FeS cluster assembly.

About this Structure

1ELQ is a Single protein structure of sequence from Synechocystis sp.. Full crystallographic information is available from OCA.

Reference

Crystal structure of the cystine C-S lyase from Synechocystis: stabilization of cysteine persulfide for FeS cluster biosynthesis., Clausen T, Kaiser JT, Steegborn C, Huber R, Kessler D, Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3856-61. PMID:10760256 Page seeded by OCA on Fri May 2 15:15:15 2008

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