1em2

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[[Image:1em2.jpg|left|200px]]
[[Image:1em2.jpg|left|200px]]
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{{Structure
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|PDB= 1em2 |SIZE=350|CAPTION= <scene name='initialview01'>1em2</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1em2", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1em2| PDB=1em2 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1em2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1em2 OCA], [http://www.ebi.ac.uk/pdbsum/1em2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1em2 RCSB]</span>
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}}
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'''STAR-RELATED LIPID TRANSPORT DOMAIN OF MLN64'''
'''STAR-RELATED LIPID TRANSPORT DOMAIN OF MLN64'''
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[[Category: Hurley, J H.]]
[[Category: Hurley, J H.]]
[[Category: Tsujishita, Y.]]
[[Category: Tsujishita, Y.]]
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[[Category: beta barrel]]
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[[Category: Beta barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:15:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:05:20 2008''
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Revision as of 12:15, 2 May 2008

Image:1em2.jpg

Template:STRUCTURE 1em2

STAR-RELATED LIPID TRANSPORT DOMAIN OF MLN64


Overview

The steroidogenic acute regulatory protein (StAR) regulates acute steroidogenesis in the adrenal cortex and gonads by promoting the translocation of cholesterol to the mitochondrial inner membrane where the first step in steriod biosynthesis is catalyzed. StAR-related lipid transfer (START) domains occur in proteins involved in lipid transport and metabolism, signal transduction, and transcriptional regulation. The 2.2 A resolution crystal structure of the START domain of human MLN64 reported here reveals an alpha/beta fold built around a U-shaped incomplete beta-barrel. The interior of the protein encompasses a 26 x 12 x 11 A hydrophobic tunnel that is large enough to bind a single cholesterol molecule. The StAR and MLN64 START domains bind 1 mole of 14C cholesterol per mole of protein in vitro. Based on the START domain structure and cholesterol binding stoichiometry, it is proposed that StAR acts by shuttling cholesterol molecules one at a time through the intermembrane space of the mitochondrion.

About this Structure

1EM2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and lipid transport mechanism of a StAR-related domain., Tsujishita Y, Hurley JH, Nat Struct Biol. 2000 May;7(5):408-14. PMID:10802740 Page seeded by OCA on Fri May 2 15:15:58 2008

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OCA

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