Histone acetyltransferase 1-2 Complex (HAT1/2)

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=Histone Modification=
=Histone Modification=
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Histones can be reversibly modified in a variety of ways, including: methylation, acetylation, phosphorylation, and ubiquitination. These modifications all result in either the condensation or relaxation of DNA and consequently repressing or activating transcription. Histone acetylation is a histone modification that involves the transfer of an acetyl group from the co-factor Acetyl Coenzyme A ([https://en.wikipedia.org/wiki/Acetyl-CoA acetyl-CoA]) to the ε-amino group of a lysine residue in a histone protein. This reaction is catalyzed by various histone acetyltransferase ([https://en.wikipedia.org/wiki/Histone_acetyltransferase HAT]) enzymes. Lysine acetylation is an important [https://en.wikipedia.org/wiki/Epigenetics epigenetic] marker as it removes the positive charge of the lysine, thus reducing the strength of the interaction between DNA and hisotones. The net effect of acetylation is the relaxation of the DNA into [https://en.wikipedia.org/wiki/Euchromatin euchromatin] which is more transcriptionally active.
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Histones can be reversibly modified in a variety of ways, including: methylation, acetylation, phosphorylation, and ubiquitination. These modifications all result in either the condensation or relaxation of DNA and consequently repressing or activating transcription. Histone acetylation is a histone modification that involves the transfer of an acetyl group from the co-factor Acetyl Coenzyme A ([https://en.wikipedia.org/wiki/Acetyl-CoA acetyl-CoA]) to the ε-amino group of a lysine residue in a histone protein. This reaction is catalyzed by various histone acetyltransferase ([https://proteopedia.org/wiki/index.php/Histone_acetyltransferase HAT]) enzymes. Lysine acetylation is an important [https://en.wikipedia.org/wiki/Epigenetics epigenetic] marker as it removes the positive charge of the lysine, thus reducing the strength of the interaction between DNA and hisotones. The net effect of acetylation is the relaxation of the DNA into [https://en.wikipedia.org/wiki/Euchromatin euchromatin] which is more transcriptionally active.
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See [[Histone acetyltransferase]].
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=HAT1 Background =
=HAT1 Background =

Revision as of 15:10, 14 June 2021

The Yeast HAT1-HAT2 Histone Acetyltransferase Complex Bound to the Histone H4 substrate

HAT1-HAT2 Complex pdb: 4psw

Drag the structure with the mouse to rotate

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