7eki
From Proteopedia
(Difference between revisions)
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==human alpha 7 nicotinic acetylcholine receptor in apo-form== | ==human alpha 7 nicotinic acetylcholine receptor in apo-form== | ||
| - | <StructureSection load='7eki' size='340' side='right'caption='[[7eki]]' scene=''> | + | <StructureSection load='7eki' size='340' side='right'caption='[[7eki]], [[Resolution|resolution]] 3.18Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EKI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EKI FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7eki]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EKI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EKI FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7eki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7eki OCA], [https://pdbe.org/7eki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7eki RCSB], [https://www.ebi.ac.uk/pdbsum/7eki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7eki ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHRNA7, NACHRA7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7eki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7eki OCA], [https://pdbe.org/7eki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7eki RCSB], [https://www.ebi.ac.uk/pdbsum/7eki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7eki ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/ACHA7_HUMAN ACHA7_HUMAN]] 15q13.3 microdeletion syndrome. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/ACHA7_HUMAN ACHA7_HUMAN]] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Liu S]] | + | [[Category: Liu, S]] |
| - | [[Category: Sun D]] | + | [[Category: Sun, D]] |
| - | [[Category: Tian C]] | + | [[Category: Tian, C]] |
| - | [[Category: Zhao Y]] | + | [[Category: Zhao, Y]] |
| + | [[Category: Alpha 7]] | ||
| + | [[Category: Apo-form]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Nicotinic acetylcholine receptor]] | ||
Revision as of 14:58, 17 June 2021
human alpha 7 nicotinic acetylcholine receptor in apo-form
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