7ekt
From Proteopedia
(Difference between revisions)
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==human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124 and PNU-120596== | ==human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124 and PNU-120596== | ||
| - | <StructureSection load='7ekt' size='340' side='right'caption='[[7ekt]]' scene=''> | + | <StructureSection load='7ekt' size='340' side='right'caption='[[7ekt]], [[Resolution|resolution]] 3.02Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EKT FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7ekt]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EKT FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ekt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ekt OCA], [https://pdbe.org/7ekt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ekt RCSB], [https://www.ebi.ac.uk/pdbsum/7ekt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ekt ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=I33:7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide'>I33</scene>, <scene name='pdbligand=I34:N-(5-Chloro-2,4-dimethoxyphenyl)-N-(5-methyl-3-isoxazolyl)-urea'>I34</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHRNA7, NACHRA7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ekt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ekt OCA], [https://pdbe.org/7ekt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ekt RCSB], [https://www.ebi.ac.uk/pdbsum/7ekt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ekt ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/ACHA7_HUMAN ACHA7_HUMAN]] 15q13.3 microdeletion syndrome. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/ACHA7_HUMAN ACHA7_HUMAN]] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Liu S]] | + | [[Category: Liu, S]] |
| - | [[Category: Sun D]] | + | [[Category: Sun, D]] |
| - | [[Category: Tian C]] | + | [[Category: Tian, C]] |
| - | [[Category: Zhao Y]] | + | [[Category: Zhao, Y]] |
| + | [[Category: Agonist]] | ||
| + | [[Category: Alpha 7]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Nicotinic acetylcholine receptor]] | ||
| + | [[Category: Pam]] | ||
Revision as of 14:59, 17 June 2021
human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124 and PNU-120596
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Categories: Human | Large Structures | Liu, S | Sun, D | Tian, C | Zhao, Y | Agonist | Alpha 7 | Membrane protein | Nicotinic acetylcholine receptor | Pam
