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2p4d

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Current revision (15:15, 17 June 2021) (edit) (undo)
 
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<StructureSection load='2p4d' size='340' side='right'caption='[[2p4d]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='2p4d' size='340' side='right'caption='[[2p4d]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2p4d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Varv Varv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P4D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2p4d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Varv Varv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P4D FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p4d OCA], [http://pdbe.org/2p4d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p4d RCSB], [http://www.ebi.ac.uk/pdbsum/2p4d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2p4d ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p4d OCA], [https://pdbe.org/2p4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p4d RCSB], [https://www.ebi.ac.uk/pdbsum/2p4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p4d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DUSP_VAR67 DUSP_VAR67]] Serine/Tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated host STAT1 and blocking interferon (IFN)-stimulated innate immune responses. Dephosphorylates the A17 protein (By similarity).
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[[https://www.uniprot.org/uniprot/DUSP_VAR67 DUSP_VAR67]] Serine/Tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated host STAT1 and blocking interferon (IFN)-stimulated innate immune responses. Dephosphorylates the A17 protein (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Current revision

Structure-assisted discovery of Variola major H1 phosphatase inhibitors

PDB ID 2p4d

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OCA

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