2p63

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==Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination==
==Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination==
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<StructureSection load='2p63' size='340' side='right' caption='[[2p63]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
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<StructureSection load='2p63' size='340' side='right'caption='[[2p63]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2p63]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P63 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P63 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2p63]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P63 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDC4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDC4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p63 OCA], [http://pdbe.org/2p63 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p63 RCSB], [http://www.ebi.ac.uk/pdbsum/2p63 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2p63 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p63 OCA], [https://pdbe.org/2p63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p63 RCSB], [https://www.ebi.ac.uk/pdbsum/2p63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p63 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CDC4_YEAST CDC4_YEAST]] Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. Directs ubiquitination of the phosphorylated CDK inhibitor SIC1. Involved in the degradation of CDC6 together with CDC34/UBC3 and CDC53, and in restricting the degradation of FAR1 to the nucleus. Is essential for initiation of DNA replication and separation of the spindle pole bodies to form the poles of the mitotic spindle. It also plays a role in bud development, fusion of zygotic nuclei after conjugation and various aspects of sporulation. Required for HTA1-HTB1 locus transcription activation. Required for G1/S and G2/M transition.<ref>PMID:7813440</ref> <ref>PMID:9346238</ref> <ref>PMID:9346239</ref> <ref>PMID:9312022</ref> <ref>PMID:9312054</ref> <ref>PMID:9736614</ref> <ref>PMID:10409741</ref> <ref>PMID:10213692</ref> <ref>PMID:11080155</ref>
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[[https://www.uniprot.org/uniprot/CDC4_YEAST CDC4_YEAST]] Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. Directs ubiquitination of the phosphorylated CDK inhibitor SIC1. Involved in the degradation of CDC6 together with CDC34/UBC3 and CDC53, and in restricting the degradation of FAR1 to the nucleus. Is essential for initiation of DNA replication and separation of the spindle pole bodies to form the poles of the mitotic spindle. It also plays a role in bud development, fusion of zygotic nuclei after conjugation and various aspects of sporulation. Required for HTA1-HTB1 locus transcription activation. Required for G1/S and G2/M transition.<ref>PMID:7813440</ref> <ref>PMID:9346238</ref> <ref>PMID:9346239</ref> <ref>PMID:9312022</ref> <ref>PMID:9312054</ref> <ref>PMID:9736614</ref> <ref>PMID:10409741</ref> <ref>PMID:10213692</ref> <ref>PMID:11080155</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Atcc 18824]]
[[Category: Atcc 18824]]
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[[Category: Large Structures]]
[[Category: Ceccarelli, D]]
[[Category: Ceccarelli, D]]
[[Category: Neculai, D]]
[[Category: Neculai, D]]

Revision as of 15:17, 17 June 2021

Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination

PDB ID 2p63

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