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Cytochrome P450 3D structures
From Proteopedia
(Difference between revisions)
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**[[3ua1]] - hP4503A4 + ergocryptine<br /> | **[[3ua1]] - hP4503A4 + ergocryptine<br /> | ||
**[[5vcg]] - hP4503A4 (mutant) + ergocryptine<br /> | **[[5vcg]] - hP4503A4 (mutant) + ergocryptine<br /> | ||
| - | **[[4ny4]], [[4d7d]], [[4d78]], [[4d75]], [[4d6z]], [[6bdm]], [[6bdk]], [[6bdi]], [[6bdh]], [[6bd8]], [[6bd7]], [[6bd6]], [[6bd5]], [[6bcz]], [[6ma8]], [[6ma7]], [[6ma6]], [[6dal]], [[6daj]], [[6dag]], [[6dac]], [[6dab]], [[6daa]], [[6da8]], [[6da5]], [[6da3]], [[6da2]], [[6une]], [[6ung]], [[6unh]], [[6uni]], [[6unj]], [[6unk]], [[6unl]], [[6unm]] - hP4503A4 + inhibitor <br /> | + | **[[4ny4]], [[4d7d]], [[4d78]], [[4d75]], [[4d6z]], [[6bdm]], [[6bdk]], [[6bdi]], [[6bdh]], [[6bd8]], [[6bd7]], [[6bd6]], [[6bd5]], [[6bcz]], [[6ma8]], [[6ma7]], [[6ma6]], [[6dal]], [[6daj]], [[6dag]], [[6dac]], [[6dab]], [[6daa]], [[6da8]], [[6da5]], [[6da3]], [[6da2]], [[6une]], [[6ung]], [[6unh]], [[6uni]], [[6unj]], [[6unk]], [[6unl]], [[6unm]], [[7ks8]], [[7ksh]], [[7kvh]], [[7kvi]], [[7kvj]], [[7kvn]], [[7kvo]], [[7kvs]] - hP4503A4 + inhibitor <br /> |
**[[5te8]] - hP4503A4 + sedation drug <br /> | **[[5te8]] - hP4503A4 + sedation drug <br /> | ||
**[[5a1p]], [[5a1r]] - hP4503A4 + progesterone <br /> | **[[5a1p]], [[5a1r]] - hP4503A4 + progesterone <br /> | ||
| + | **[[7lxl]] - hP4503A4 + testosterone <br /> | ||
**[[6mjm]] - hP4503A5 <br /> | **[[6mjm]] - hP4503A5 <br /> | ||
**[[5veu]] - hP4503A5 + inhibitor<br /> | **[[5veu]] - hP4503A5 + inhibitor<br /> | ||
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* human P450 17 A1 family (steroid 17-α-hydroxylase 17,20 lyase) | * human P450 17 A1 family (steroid 17-α-hydroxylase 17,20 lyase) | ||
| - | **[[5uys]], [[3ruk]], [[6chi]], [[6cir]], [[6ciz]] - hP450 C17 + abiraterone derivative<br /> | + | **[[5uys]], [[3ruk]], [[6chi]], [[6cir]], [[6ciz]], [[6wr0]], [[6ww0]] - hP450 C17 + abiraterone derivative<br /> |
| - | **[[4nkv]] - hP450 C17 (mutant) + abiraterone derivative<br /> | + | **[[4nkv]], [[6wr1]] - hP450 C17 (mutant) + abiraterone derivative<br /> |
**[[5irq]] - hP450 C17 + orteronel<br /> | **[[5irq]] - hP450 C17 + orteronel<br /> | ||
**[[5irv]] - hP450 C17 + inhibitor<br /> | **[[5irv]] - hP450 C17 + inhibitor<br /> | ||
| Line 147: | Line 148: | ||
* P450cam or camphor-5 momooxygenase | * P450cam or camphor-5 momooxygenase | ||
| - | **[[1dz4]], [[1dz8]], [[1dz6]], [[1dz9]], [[5cp4]], [[1phc]], [[2cpp]], [[1yrc]], [[1yrd]], [[3l61]], [[3l62]], [[3l63]], [[3wrh]], [[3wri]], [[3wrk]] - PpP450cam - ''Pseudomona putida''<br /> | + | **[[1dz4]], [[1dz8]], [[1dz6]], [[1dz9]], [[5cp4]], [[1phc]], [[2cpp]], [[1yrc]], [[1yrd]], [[3l61]], [[3l62]], [[3l63]], [[3wrh]], [[3wri]], [[3wrk]], [[6wpl]] - PpP450cam - ''Pseudomona putida''<br /> |
**[[2qbl]], [[2qbm]], [[2qbn]], [[2gqx]], [[2gr6]], [[2frz]], [[2h7s]], [[6cp4]], [[2cp4]], [[3cp4]], [[4cp4]], [[1c8j]], [[1geb]], [[2a1o]], [[3p6q]], [[3p6r]], [[3p6s]], [[3p6t]], [[3p6u]], [[3p6v]], [[3p6w]], [[3p6x]], [[4ek1]], [[5wk7]], [[6we6]], [[6wfl]] – PpP450cam (mutant) <br /> | **[[2qbl]], [[2qbm]], [[2qbn]], [[2gqx]], [[2gr6]], [[2frz]], [[2h7s]], [[6cp4]], [[2cp4]], [[3cp4]], [[4cp4]], [[1c8j]], [[1geb]], [[2a1o]], [[3p6q]], [[3p6r]], [[3p6s]], [[3p6t]], [[3p6u]], [[3p6v]], [[3p6w]], [[3p6x]], [[4ek1]], [[5wk7]], [[6we6]], [[6wfl]] – PpP450cam (mutant) <br /> | ||
**[[2qbo]] - PpP450cam (mutant)+cyanide<br /> | **[[2qbo]] - PpP450cam (mutant)+cyanide<br /> | ||
| Line 278: | Line 279: | ||
**[[3p3l]], [[3p3o]], [[3p3x]], [[3p3z]] – P450 – ''Streptomyces thioluteus''<br /> | **[[3p3l]], [[3p3o]], [[3p3x]], [[3p3z]] – P450 – ''Streptomyces thioluteus''<br /> | ||
**[[2rfb]] – PtP450 – ''Picrophilus torridus''<br /> | **[[2rfb]] – PtP450 – ''Picrophilus torridus''<br /> | ||
| - | **[[6gii]] – P450 – ''Tepidiphilus thermophilus''<br /> | + | **[[6gii]], [[6laa]] – P450 – ''Tepidiphilus thermophilus''<br /> |
**[[1wiy]] – TtP450 – ''Thermus thermophilus''<br /> | **[[1wiy]] – TtP450 – ''Thermus thermophilus''<br /> | ||
**[[4e2p]], [[5xw2]] - P450 – ''Streptococcus himastatinicus''<br /> | **[[4e2p]], [[5xw2]] - P450 – ''Streptococcus himastatinicus''<br /> | ||
| Line 284: | Line 285: | ||
**[[5ysm]] – AmP450 – ''Amycolatopsis mediterranei''<br /> | **[[5ysm]] – AmP450 – ''Amycolatopsis mediterranei''<br /> | ||
**[[6f0c]], [[6f0b]] - P450 TXTC – ''Streptomyces acidiscabies''<br /> | **[[6f0c]], [[6f0b]] - P450 TXTC – ''Streptomyces acidiscabies''<br /> | ||
| - | **[[5gwe]] – CgP450 | + | **[[5gwe]], [[7ccf]] – CgP450 CreJ – ''Corynebacterium glutamicum''<br /> |
**[[5y1i]] - P450 GFSF – ''Streptomyces graminofaciens''<br /> | **[[5y1i]] - P450 GFSF – ''Streptomyces graminofaciens''<br /> | ||
**[[1cpt]] – PsP450 TERP - ''Pseudomonas sp.''<br /> | **[[1cpt]] – PsP450 TERP - ''Pseudomonas sp.''<br /> | ||
| Line 293: | Line 294: | ||
**[[3qi8]] – P450 – synthetic<br /> | **[[3qi8]] – P450 – synthetic<br /> | ||
**[[6mi0]] – McP450 CYP51 – ''Methylcoccus capsulatus''<br /> | **[[6mi0]] – McP450 CYP51 – ''Methylcoccus capsulatus''<br /> | ||
| + | **[[6ay4]], [[6ayb]], [[6ayc]] – P450 CYP51 + drug – ''Naegleria fowleri''<br /> | ||
**[[3dam]], [[3dan]], [[3dbm]] – P45074A2 – ''Parthenium argentatum''<br /> | **[[3dam]], [[3dan]], [[3dbm]] – P45074A2 – ''Parthenium argentatum''<br /> | ||
**[[2rcm]], [[3cli]] - AtP45074A - ''Arabidopsis thaliana''<br /> | **[[2rcm]], [[3cli]] - AtP45074A - ''Arabidopsis thaliana''<br /> | ||
| Line 303: | Line 305: | ||
**[[3abb]] – SaP450 CYP105D6 - ''Streptomyces avermitilis''<br /> | **[[3abb]] – SaP450 CYP105D6 - ''Streptomyces avermitilis''<br /> | ||
**[[3e5j]], [[3e5l]] - SaP450 CYP105P1 (mutant)<br /> | **[[3e5j]], [[3e5l]] - SaP450 CYP105P1 (mutant)<br /> | ||
| - | **[[2z3u]] - | + | **[[2z3u]] - SgP450 CYP105A1 (mutant) – ''Streptomyces griseolus''<br /> |
**[[5xnt]] - P450 CYP106A2 – ''Bacillus butanolivorans''<br /> | **[[5xnt]] - P450 CYP106A2 – ''Bacillus butanolivorans''<br /> | ||
| + | **[[6l39]] - SrP450 CYP107G1 – ''Streptomyces rapamycinicus''<br /> | ||
**[[4wpz]] - SaP450 CYP107W1 <br /> | **[[4wpz]] - SaP450 CYP107W1 <br /> | ||
**[[2whw]], [[2wi9]], [[2vz7]] – SvP450107L1 (mutant) – ''Streptomyces venezuelae''<br /> | **[[2whw]], [[2wi9]], [[2vz7]] – SvP450107L1 (mutant) – ''Streptomyces venezuelae''<br /> | ||
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**[[6hqg]] - P450 CYP153 – ''Phenylobacterium zucineum''<br /> | **[[6hqg]] - P450 CYP153 – ''Phenylobacterium zucineum''<br /> | ||
**[[6hqd]] – PsP450 CYP153 <br /> | **[[6hqd]] – PsP450 CYP153 <br /> | ||
| + | **[[7ant]] – PoP450 CYP153 - ''Polaromonas''<br /> | ||
**[[1gwi]] - ScP450 CYP154C1<br /> | **[[1gwi]] - ScP450 CYP154C1<br /> | ||
**[[6a7i]] - SvP450 CYP154C4 – ''Streptomyces violaceruber''<br /> | **[[6a7i]] - SvP450 CYP154C4 – ''Streptomyces violaceruber''<br /> | ||
| Line 336: | Line 340: | ||
**[[6gk5]] - ScP450 CYP267B1 <br /> | **[[6gk5]] - ScP450 CYP267B1 <br /> | ||
**[[6g71]] - P450 CYP1232A24 - ''Arthrobacter''<br /> | **[[6g71]] - P450 CYP1232A24 - ''Arthrobacter''<br /> | ||
| + | **[[6m4q]] - SspP450 – ''Streptomyces spectabilis''<br /> | ||
| + | **[[6j82]] - SbP450 TleB – ''Streptomyces blastmyceticus''<br /> | ||
| + | **[[6kbh]] – ReP450 – ''Rhodococcus erythropolis''<br /> | ||
*Other CYPs complexes | *Other CYPs complexes | ||
**[[2rfc]] – PtP450+phenylimidazole<br /> | **[[2rfc]] – PtP450+phenylimidazole<br /> | ||
| - | **[[3wec]] – | + | **[[3wec]] – ReP450 + dihydroxy-aurachin Re <br /> |
**[[5ysw]] – AmP450+ rifamycin <br /> | **[[5ysw]] – AmP450+ rifamycin <br /> | ||
**[[5omu]] – AmP450+ syringol <br /> | **[[5omu]] – AmP450+ syringol <br /> | ||
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**[[3cv9]], [[2zbz]] - SgP450 CYP105A1 (mutant)+vitamin D3<br /> | **[[3cv9]], [[2zbz]] - SgP450 CYP105A1 (mutant)+vitamin D3<br /> | ||
**[[2zbx]] - SgP450 CYP105A1+imidazole<br /> | **[[2zbx]] - SgP450 CYP105A1+imidazole<br /> | ||
| - | **[[5x7e]] - | + | **[[5x7e]] - SgP450 CYP105A1 (mutant)+vitamin D2<br / |
**[[3aba]] – SaP450 CYP105P1+filipin I <br /> | **[[3aba]] – SaP450 CYP105P1+filipin I <br /> | ||
**[[3e5k]] - SaP450 CYP105P1 (mutant)+4-phenylimidazole<br /> | **[[3e5k]] - SaP450 CYP105P1 (mutant)+4-phenylimidazole<br /> | ||
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**[[1eup]] – SeP450 CYP107A1+androstendione<br /> | **[[1eup]] – SeP450 CYP107A1+androstendione<br /> | ||
**[[1egy]] - SeP450 CYP107A1+aminophenanthrene<br /> | **[[1egy]] - SeP450 CYP107A1+aminophenanthrene<br /> | ||
| + | **[[6kzs]] - SgP450 CYP107F1 + imidazole<br /> | ||
| + | **[[6l3a]] - SrP450 CYP107G1 + drug<br /> | ||
**[[4wq0]] - SaP450 CYP107W1 + oligomycin<br /> | **[[4wq0]] - SaP450 CYP107W1 + oligomycin<br /> | ||
**[[2vzm]] – SvP450 CYP107L1 (mutant)+narbomycin<br /> | **[[2vzm]] – SvP450 CYP107L1 (mutant)+narbomycin<br /> | ||
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**[[5yhj]] - P450 CYP152N1 + myristic acid - ''Exiguobacterium''<br /> | **[[5yhj]] - P450 CYP152N1 + myristic acid - ''Exiguobacterium''<br /> | ||
**[[5fyg]] - MhP450 CYP153A + dodecanoic acid<br /> | **[[5fyg]] - MhP450 CYP153A + dodecanoic acid<br /> | ||
| + | **[[7ao7]] – PoP450 CYP153 + octanol <br /> | ||
| + | **[[6to2]] - NfP450 CYP154C4 + androstan derivative – ''Nocardia farcinica'' <br /> | ||
| + | **[[4j6b]], [[4jbc]], [[4jbd]], [[4jbt]] - NfP450 CYP154C5 + hormone<br /> | ||
**[[6a7j]] - SvP450 CYP154C4 + testosterone <br /> | **[[6a7j]] - SvP450 CYP154C4 + testosterone <br /> | ||
**[[3r9c]] – MsP450 CYP164A2 + econazole<br /> | **[[3r9c]] – MsP450 CYP164A2 + econazole<br /> | ||
| - | **[[4do1]], [[4egm]], [[6c3j]], [[6c3h]], [[6c2d]], [[5yqh]], [[5yqa]], [[5uvb]], [[5u6w]], [[5u6u]], [[5u6t]], [[5kt1]], [[5kdb]], [[6oow]], [[6pq6]], [[6pqd]], [[6pqs]], [[6pqw]], [[6prr]], [[6prs]], [[6u30]], [[6u3k]] – RpP450 CYP199A4 + benzoate derivative<br /> | + | **[[4do1]], [[4egm]], [[6c3j]], [[6c3h]], [[6c2d]], [[5yqh]], [[5yqa]], [[5uvb]], [[5u6w]], [[5u6u]], [[5u6t]], [[5kt1]], [[5kdb]], [[6oow]], [[6pq6]], [[6pqd]], [[6pqs]], [[6pqw]], [[6prr]], [[6prs]], [[6u30]], [[6u31]], [[6u3k]] – RpP450 CYP199A4 + benzoate derivative<br /> |
**[[5kdz]], [[5kdy]], [[6oox]] – RpP450 CYP199A4 (mutant) + benzoate derivative<br /> | **[[5kdz]], [[5kdy]], [[6oox]] – RpP450 CYP199A4 (mutant) + benzoate derivative<br /> | ||
**[[4egn]] – RpP450 CYP199A4 + veratric acid<br /> | **[[4egn]] – RpP450 CYP199A4 + veratric acid<br /> | ||
**[[4egp]] – RpP450 CYP199A4 + naphthoic acid<br /> | **[[4egp]] – RpP450 CYP199A4 + naphthoic acid<br /> | ||
| + | **[[46unn]] – RpP450 CYP199A4 + cinnamic acid derivative<br /> | ||
**[[4ego]] – RpP450 CYP199A4 + indole derivative<br /> | **[[4ego]] – RpP450 CYP199A4 + indole derivative<br /> | ||
**[[3a1l]] – StrP450 CYP245A1+dichlorochrompyrrolic acid <br /> | **[[3a1l]] – StrP450 CYP245A1+dichlorochrompyrrolic acid <br /> | ||
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**[[4r20]] - zP450 17A2 + abiraterone – zebra fish<br /> | **[[4r20]] - zP450 17A2 + abiraterone – zebra fish<br /> | ||
**[[6b82]] - zP450 17A1 (mutant) + abiraterone <br /> | **[[6b82]] - zP450 17A1 (mutant) + abiraterone <br /> | ||
| + | **[[6m4p]] - SspP450 + antibiotic <br /> | ||
| + | **[[6zi3]] - P450 + rhamnose – ''Streptomyces antibioticus''<br /> | ||
| + | **[[6j84]] - SbP450 TleB + hydroxyl analog<br /> | ||
| + | **[[6j83]] - SbP450 TleB + NMVT<br /> | ||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:28, 22 June 2021
3D Structures of Cytochrome P450
Updated on 22-June-2021
