1eoo

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[[Image:1eoo.gif|left|200px]]
[[Image:1eoo.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1eoo |SIZE=350|CAPTION= <scene name='initialview01'>1eoo</scene>, resolution 2.16&Aring;
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The line below this paragraph, containing "STRUCTURE_1eoo", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Type_II_site-specific_deoxyribonuclease Type II site-specific deoxyribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.21.4 3.1.21.4] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1eoo| PDB=1eoo | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eoo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eoo OCA], [http://www.ebi.ac.uk/pdbsum/1eoo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1eoo RCSB]</span>
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}}
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'''ECORV BOUND TO COGNATE DNA'''
'''ECORV BOUND TO COGNATE DNA'''
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[[Category: Horton, N C.]]
[[Category: Horton, N C.]]
[[Category: Perona, J J.]]
[[Category: Perona, J J.]]
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[[Category: endonuclease]]
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[[Category: Endonuclease]]
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[[Category: induced fit]]
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[[Category: Induced fit]]
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[[Category: protein-dna recognition]]
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[[Category: Protein-dna recognition]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:21:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:06:45 2008''
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Revision as of 12:21, 2 May 2008

Image:1eoo.gif

Template:STRUCTURE 1eoo

ECORV BOUND TO COGNATE DNA


Overview

Two new high-resolution cocrystal structures of EcoRV endonuclease bound to DNA show that a large variation in DNA-bending angles is sampled in the ground state binary complex. Together with previous structures, these data reveal a contiguous series of protein conformational states delineating a specific trajectory for the induced-fit pathway. Rotation of the DNA-binding domains, together with movements of two symmetry-related helices binding in the minor groove, causes base unstacking at a key base-pair step and propagates structural changes that assemble the active sites. These structures suggest a complex mechanism for DNA bending that depends on forces generated by interacting protein segments, and on selective neutralization of phosphate charges along the inner face of the bent double helix.

About this Structure

1EOO is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystallographic snapshots along a protein-induced DNA-bending pathway., Horton NC, Perona JJ, Proc Natl Acad Sci U S A. 2000 May 23;97(11):5729-34. PMID:10801972 Page seeded by OCA on Fri May 2 15:21:18 2008

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OCA

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