6xau
From Proteopedia
(Difference between revisions)
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==Structure of the PR domain from PRDM3== | ==Structure of the PR domain from PRDM3== | ||
| - | <StructureSection load='6xau' size='340' side='right'caption='[[6xau]]' scene=''> | + | <StructureSection load='6xau' size='340' side='right'caption='[[6xau]], [[Resolution|resolution]] 1.89Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XAU FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6xau]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XAU FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xau OCA], [https://pdbe.org/6xau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xau RCSB], [https://www.ebi.ac.uk/pdbsum/6xau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xau ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mecom, Evi1, Mds1, Prdm3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xau OCA], [https://pdbe.org/6xau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xau RCSB], [https://www.ebi.ac.uk/pdbsum/6xau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xau ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/MECOM_MOUSE MECOM_MOUSE]] Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.<ref>PMID:15889140</ref> <ref>PMID:18619962</ref> <ref>PMID:19767769</ref> Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation.<ref>PMID:22939622</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Briknarova K]] | + | [[Category: Lk3 transgenic mice]] |
| - | [[Category: Loa S]] | + | [[Category: Briknarova, K]] |
| - | [[Category: Mou | + | [[Category: Loa, S]] |
| - | [[Category: Sprang | + | [[Category: Mou, T C]] |
| + | [[Category: Sprang, S R]] | ||
| + | [[Category: Prdm3]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 07:42, 25 June 2021
Structure of the PR domain from PRDM3
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