2q3e
From Proteopedia
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==Structure of human UDP-glucose dehydrogenase complexed with NADH and UDP-glucose==  | ==Structure of human UDP-glucose dehydrogenase complexed with NADH and UDP-glucose==  | ||
| - | <StructureSection load='2q3e' size='340' side='right' caption='[[2q3e]], [[Resolution|resolution]] 2.00Å' scene=''>  | + | <StructureSection load='2q3e' size='340' side='right'caption='[[2q3e]], [[Resolution|resolution]] 2.00Å' scene=''>  | 
== Structural highlights ==  | == Structural highlights ==  | ||
| - | <table><tr><td colspan='2'>[[2q3e]] is a 12 chain structure with sequence from [  | + | <table><tr><td colspan='2'>[[2q3e]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q3E FirstGlance]. <br>  | 
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=UPG:URIDINE-5-DIPHOSPHATE-GLUCOSE'>UPG</scene></td></tr>  | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=UPG:URIDINE-5-DIPHOSPHATE-GLUCOSE'>UPG</scene></td></tr>  | 
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UGDH ([  | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UGDH ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>  | 
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[  | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/UDP-glucose_6-dehydrogenase UDP-glucose 6-dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.22 1.1.1.22] </span></td></tr>  | 
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[  | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q3e OCA], [https://pdbe.org/2q3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q3e RCSB], [https://www.ebi.ac.uk/pdbsum/2q3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q3e ProSAT]</span></td></tr>  | 
</table>  | </table>  | ||
== Function ==  | == Function ==  | ||
| - | [[  | + | [[https://www.uniprot.org/uniprot/UGDH_HUMAN UGDH_HUMAN]] Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.   | 
== Evolutionary Conservation ==  | == Evolutionary Conservation ==  | ||
[[Image:Consurf_key_small.gif|200px|right]]  | [[Image:Consurf_key_small.gif|200px|right]]  | ||
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</div>  | </div>  | ||
<div class="pdbe-citations 2q3e" style="background-color:#fffaf0;"></div>  | <div class="pdbe-citations 2q3e" style="background-color:#fffaf0;"></div>  | ||
| + | |||
| + | ==See Also==  | ||
| + | *[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]  | ||
== References ==  | == References ==  | ||
<references/>  | <references/>  | ||
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</StructureSection>  | </StructureSection>  | ||
[[Category: Human]]  | [[Category: Human]]  | ||
| + | [[Category: Large Structures]]  | ||
[[Category: UDP-glucose 6-dehydrogenase]]  | [[Category: UDP-glucose 6-dehydrogenase]]  | ||
[[Category: Arrowsmith, C]]  | [[Category: Arrowsmith, C]]  | ||
Revision as of 08:06, 25 June 2021
Structure of human UDP-glucose dehydrogenase complexed with NADH and UDP-glucose
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Categories: Human | Large Structures | UDP-glucose 6-dehydrogenase | Arrowsmith, C | Berridge, G | Bhatia, C | Bunkoczi, G | Delft, F von | Edwards, A | Guo, K | Kavanagh, K L | Oppermann, U | Pilka, E | Structural genomic | Savitsky, P | Smee, C | Sundstrom, M | Wiegelt, J | Hexamer | Oxidoreductase | Sgc | Udp-glucose 6-dehydrogenase

