2q87

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==The Crystal Structure of the Human IRp60 Ectodomain==
==The Crystal Structure of the Human IRp60 Ectodomain==
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<StructureSection load='2q87' size='340' side='right' caption='[[2q87]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='2q87' size='340' side='right'caption='[[2q87]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2q87]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q87 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q87 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2q87]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q87 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q87 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2nms|2nms]], [[1zox|1zox]], [[1xed|1xed]], [[1hkf|1hkf]], [[2frg|2frg]], [[1smo|1smo]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2nms|2nms]], [[1zox|1zox]], [[1xed|1xed]], [[1hkf|1hkf]], [[2frg|2frg]], [[1smo|1smo]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD300A, CMRF35H ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD300A, CMRF35H ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q87 OCA], [http://pdbe.org/2q87 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q87 RCSB], [http://www.ebi.ac.uk/pdbsum/2q87 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2q87 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q87 OCA], [https://pdbe.org/2q87 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q87 RCSB], [https://www.ebi.ac.uk/pdbsum/2q87 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q87 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CLM8_HUMAN CLM8_HUMAN]] Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation.<ref>PMID:10746781</ref> <ref>PMID:16339535</ref> <ref>PMID:9701027</ref>
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[[https://www.uniprot.org/uniprot/CLM8_HUMAN CLM8_HUMAN]] Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation.<ref>PMID:10746781</ref> <ref>PMID:16339535</ref> <ref>PMID:9701027</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/2q87_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/2q87_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Dimasi, N]]
[[Category: Dimasi, N]]
[[Category: Marquez, J A]]
[[Category: Marquez, J A]]

Revision as of 08:11, 25 June 2021

The Crystal Structure of the Human IRp60 Ectodomain

PDB ID 2q87

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