1ep4

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[[Image:1ep4.jpg|left|200px]]
[[Image:1ep4.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1ep4 |SIZE=350|CAPTION= <scene name='initialview01'>1ep4</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1ep4", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CSW:CYSTEINE-S-DIOXIDE'>CSW</scene>, <scene name='pdbligand=S11:5-(3,5-DICHLOROPHENYL)THIO-4-ISOPROPYL-1-(PYRIDIN-4-YL-METHYL)-1H-IMIDAZOL-2-YL-METHYL+CARBAMATE'>S11</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1ep4| PDB=1ep4 | SCENE= }}
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|RELATEDENTRY=[[1vrt|1VRT]], [[1rth|1RTH]], [[1vru|1VRU]], [[1rti|1RTI]], [[1rtj|1RTJ]], [[1rev|1REV]], [[1rt1|1RT1]], [[1rt2|1RT2]], [[1klm|1KLM]], [[1rt3|1RT3]], [[1rt4|1RT4]], [[1rt5|1RT5]], [[1rt6|1RT6]], [[1rt7|1RT7]], [[1c0t|1C0T]], [[1c0u|1C0U]], [[1c1b|1C1B]], [[1c1c|1C1C]], [[1dtq|1DTQ]], [[1dtt|1DTT]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ep4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ep4 OCA], [http://www.ebi.ac.uk/pdbsum/1ep4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ep4 RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH S-1153'''
'''CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH S-1153'''
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[[Category: Stuart, D I.]]
[[Category: Stuart, D I.]]
[[Category: Suginoto, H.]]
[[Category: Suginoto, H.]]
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[[Category: aid]]
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[[Category: Aid]]
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[[Category: drug design]]
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[[Category: Drug design]]
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[[Category: hiv-1 reverse transcriptase]]
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[[Category: Hiv-1 reverse transcriptase]]
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[[Category: non-nucleoside inhibitor]]
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[[Category: Non-nucleoside inhibitor]]
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[[Category: s-1153]]
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[[Category: S-1153]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:22:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:06:58 2008''
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Revision as of 12:22, 2 May 2008

Image:1ep4.jpg

Template:STRUCTURE 1ep4

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH S-1153


Overview

S-1153 (AG1549) is perhaps the most promising non-nucleoside inhibitor of HIV-1 reverse transcriptase currently under development as a potential anti-AIDS drug, because it has a favorable profile of resilience to many drug resistance mutations. We have determined the crystal structure of S-1153 in a complex with HIV-1 reverse transcriptase. The complex possesses some novel features, including an extensive network of hydrogen bonds involving the main chain of residues 101, 103, and 236 of the p66 reverse transcriptase subunit. Such interactions are unlikely to be disrupted by side chain mutations. The reverse transcriptase/S-1153 complex suggests different ways in which resilience to mutations in the non-nucleoside inhibitors of reverse transcriptase binding site can be achieved.

About this Structure

1EP4 is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Binding of the second generation non-nucleoside inhibitor S-1153 to HIV-1 reverse transcriptase involves extensive main chain hydrogen bonding., Ren J, Nichols C, Bird LE, Fujiwara T, Sugimoto H, Stuart DI, Stammers DK, J Biol Chem. 2000 May 12;275(19):14316-20. PMID:10799511 Page seeded by OCA on Fri May 2 15:22:07 2008

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