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Dihydrofolate reductase 3D structures
From Proteopedia
(Difference between revisions)
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*DHFR-Thymidine synthase (TS) complex | *DHFR-Thymidine synthase (TS) complex | ||
| + | **[[6pfi]] - hDHFR-TS + NADPH + dUMP + pyrimidine derivative <br /> | ||
**[[3cl9]], [[2h2q]], [[3qfx]] – TcDHFR-TS - ''Trypanosoma cruzi''<br /> | **[[3cl9]], [[2h2q]], [[3qfx]] – TcDHFR-TS - ''Trypanosoma cruzi''<br /> | ||
**[[1qzf]] - ChTcDHFR-TS – ''Cryptosporidium hominis''<br /> | **[[1qzf]] - ChTcDHFR-TS – ''Cryptosporidium hominis''<br /> | ||
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**[[3dg8]], [[1j3i]], [[3dga]], [[3qgt]], [[6a2k]], [[6a2m]], [[6a2o]] - PfDHFR-TS+NADPH +dUMP+inhibitor – ''Plasmodium falciparum''<br /> | **[[3dg8]], [[1j3i]], [[3dga]], [[3qgt]], [[6a2k]], [[6a2m]], [[6a2o]] - PfDHFR-TS+NADPH +dUMP+inhibitor – ''Plasmodium falciparum''<br /> | ||
**[[1j3k]], [[1j3j]], [[3jsu]], [[6a2l]], [[6a2n]], [[6a2p]] - PfDHFR-TS (mutant)+NADPH+dUMP+ inhibitor<br /> | **[[1j3k]], [[1j3j]], [[3jsu]], [[6a2l]], [[6a2n]], [[6a2p]] - PfDHFR-TS (mutant)+NADPH+dUMP+ inhibitor<br /> | ||
| - | **[[3qg2]] - PfDHFR-TS (mutant)+NADPH + inhibitor<br /> | + | **[[7ctw]], [[7cty]] - PfDHFR-TS +NADPH+ inhibitor<br /> |
| + | **[[3qg2]], [[6leu]], [[6lev]], [[6lez]], [[6lh9]], [[6lhi]], [[6lhj]] - PfDHFR-TS (mutant)+NADPH + inhibitor<br /> | ||
**[[3um8]], [[4dph]], [[6kot]] - PfDHFR-TS + NADPH + anti-malarial drug<br /> | **[[3um8]], [[4dph]], [[6kot]] - PfDHFR-TS + NADPH + anti-malarial drug<br /> | ||
**[[3um5]], [[3um6]], [[4dp3]], [[6kp2]], [[6kp7]], [[6kpr]] - PfDHFR-TS (mutant)+NADPH + dUMP + anti-malarial drug<br /> | **[[3um5]], [[3um6]], [[4dp3]], [[6kp2]], [[6kp7]], [[6kpr]] - PfDHFR-TS (mutant)+NADPH + dUMP + anti-malarial drug<br /> | ||
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**[[4or7]], [[4osg]], [[5ecc]], [[5ecx]] - DHFR +NADPH + pyrimidine derivative – ''Klebsiella pneumoniae'' <br /> | **[[4or7]], [[4osg]], [[5ecc]], [[5ecx]] - DHFR +NADPH + pyrimidine derivative – ''Klebsiella pneumoniae'' <br /> | ||
**[[6cxm]] - MsDHFR +NADPH + pyrimidine derivative – ''Mycobacterium smegmatis''<br /> | **[[6cxm]] - MsDHFR +NADPH + pyrimidine derivative – ''Mycobacterium smegmatis''<br /> | ||
| + | **[[7k6c]] – DHFR (mutant) + NADPH + pyrimidine derivative –'' Mycobacterioides abscessus''<br /> | ||
| + | **[[6uwq]], [[6uww]] – MuDHFR + NADPH + pyrimidine derivative – ''Mycobacterium ulcerans''<br /> | ||
| + | **[[7k68]], [[7k6a]] – MuDHFR (mutant) + NADPH + pyrimidine derivative <br /> | ||
*''Ternary complexes with quinazoline derivative'' | *''Ternary complexes with quinazoline derivative'' | ||
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*''Ternary complexes with TMP'' | *''Ternary complexes with TMP'' | ||
| + | **[[2w3a]] – hDHFR +TMP+NADPH<BR /> | ||
| + | **[[1yho]] - hDHFR+NADPH+ TMP – NMR<BR /> | ||
| + | **[[2fzi]], [[2fzj]] - mDHFR+NADPH+ TMP<br /> | ||
**[[2w9g]] - SaDHFR+ TMP +NADPH<BR /> | **[[2w9g]] - SaDHFR+ TMP +NADPH<BR /> | ||
**[[3fre]], [[2w9s]], [[3frb]] – SaDHFR (mutant)+TMP+NADPH<BR /> | **[[3fre]], [[2w9s]], [[3frb]] – SaDHFR (mutant)+TMP+NADPH<BR /> | ||
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**[[3s9u]], [[3sa1]], [[3sa2]], [[3sai]] – BaDHFR (mutant) +TMP analog + NADP<br /> | **[[3s9u]], [[3sa1]], [[3sa2]], [[3sai]] – BaDHFR (mutant) +TMP analog + NADP<br /> | ||
**[[1lud]] - LcDHFR+NADPH+ TMP – NMR<BR /> | **[[1lud]] - LcDHFR+NADPH+ TMP – NMR<BR /> | ||
| - | + | **[[2fzh]] – PcDHFR+NADPH+ TMP <br /> | |
| - | **[[2fzh]] – PcDHFR+NADPH+ TMP <br | + | |
| - | + | ||
| - | + | ||
**[[1dg5]] - MtDHFR + TMP +NADPH<BR /> | **[[1dg5]] - MtDHFR + TMP +NADPH<BR /> | ||
**[[4km2]] - MtDHFR + ADP + TMP<br /> | **[[4km2]] - MtDHFR + ADP + TMP<br /> | ||
| + | **[[6xg4]], [[6xg5]] - EcDHFR+NADPH+ TMP<br /> | ||
*''Ternary complexes with MTX'' | *''Ternary complexes with MTX'' | ||
**[[1u71]], [[1u72]] - hDHFR (mutant)+MTX+NADPH<BR /> | **[[1u71]], [[1u72]] - hDHFR (mutant)+MTX+NADPH<BR /> | ||
| + | **[[1u70]] – mDHFR (mutant)+MTX+NADPH<BR /> | ||
**[[3ia4]] – MpDHFR+ MTX +NADPH<BR /> | **[[3ia4]] – MpDHFR+ MTX +NADPH<BR /> | ||
**[[3dat]] - BaDHFR+ MTX+NADPH<BR /> | **[[3dat]] - BaDHFR+ MTX+NADPH<BR /> | ||
**[[1bzf]] - LcDHFR+NADPH+ TMX – NMR<BR /> | **[[1bzf]] - LcDHFR+NADPH+ TMX – NMR<BR /> | ||
| - | **[[1u70]] – mDHFR (mutant)+MTX+NADPH<BR /> | ||
**[[1dre]], [[1rb3]], [[1rg7]], [[1rh3]], [[1ra3]], [[1rx3]], [[3dau]], [[4gh8]] - EcDHFR+NADP+MTX<br /> | **[[1dre]], [[1rb3]], [[1rg7]], [[1rh3]], [[1ra3]], [[1rx3]], [[3dau]], [[4gh8]] - EcDHFR+NADP+MTX<br /> | ||
**[[1ddr]] - EcDHFR+MTX+urea<br /> | **[[1ddr]] - EcDHFR+MTX+urea<br /> | ||
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**[[1vj3]] – PcHDFR+TAB+NADPH <br /> | **[[1vj3]] – PcHDFR+TAB+NADPH <br /> | ||
**[[4m2x]] - MtDHFR + trimetrexate +NADPH<br /> | **[[4m2x]] - MtDHFR + trimetrexate +NADPH<br /> | ||
| - | **[[6nnd]] - MtDHFR + DHF +NADPH<br /> | ||
**[[6nnh]] - MtDHFR + cycloguanyl +NADPH<br /> | **[[6nnh]] - MtDHFR + cycloguanyl +NADPH<br /> | ||
**[[6nni]] - MtDHFR + pyrimethamine +NADPH<br /> | **[[6nni]] - MtDHFR + pyrimethamine +NADPH<br /> | ||
**[[4kne]] - MtDHFR + ADP + anti-folate drug<br /> | **[[4kne]] - MtDHFR + ADP + anti-folate drug<br /> | ||
**[[1dg7]] - MtDHFR + 4-Br-WR99210 +NADPH<BR /> | **[[1dg7]] - MtDHFR + 4-Br-WR99210 +NADPH<BR /> | ||
| + | **[[6vs6]], [[6vs8]], [[6vs9]], [[6vsb]], [[6vsd]], [[6vse]], [[6vsf]], [[6vsg]] - MtDHFR + inhibitor +NADPH<BR /> | ||
*DHFR higher complexes | *DHFR higher complexes | ||
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*DHFR+ligands | *DHFR+ligands | ||
| - | **[[2w3m]], [[4m6k]], [[6dav]] – hDHFR +folate+NADPH<BR /> | + | **[[2w3m]], [[4m6k]], [[6dav]], [[7ese]] – hDHFR +folate+NADPH<BR /> |
**[[1drf]] - hDHFR +folate<br /> | **[[1drf]] - hDHFR +folate<br /> | ||
**[[1dhf]], [[2dhf]] – hDHFR+folate+5-deazofolate<br /> | **[[1dhf]], [[2dhf]] – hDHFR+folate+5-deazofolate<br /> | ||
**[[4m6l]] - hDHFR+folate+ NADPH + folate derivative<br /> | **[[4m6l]] - hDHFR+folate+ NADPH + folate derivative<br /> | ||
| + | **[[6vcj]] - hDHFR+folate+ NADPH + pyrimidine derivative + drug<br /> | ||
**[[1e26]] - PcDHFR-TS+NADP+folate<br /> | **[[1e26]] - PcDHFR-TS+NADP+folate<br /> | ||
**[[2jyb]] – HvDHFR+folate<br /> | **[[2jyb]] – HvDHFR+folate<br /> | ||
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**[[7dfr]] - EcDHFR+NAP+NADP+folate<br /> | **[[7dfr]] - EcDHFR+NAP+NADP+folate<br /> | ||
**[[1ra8]], [[1rx8]], [[1rx4]] – EcDHFR+folate+ ADP derivative<br /> | **[[1ra8]], [[1rx8]], [[1rx4]] – EcDHFR+folate+ ADP derivative<br /> | ||
| - | **[[1rb2]], [[1rx2]], [[1ra2]], [[3ql3]], [[4kjj]], [[4kjk]], [[4nx6]], [[4nx7]], [[4pss]], [[4pst]], [[4psy]], [[4pth]], [[4ptj]], [[4rgc]], [[4x5f]], [[4x5g]], [[4x5h]], [[4x5i]], [[4x5j]], [[1dyl]] | + | **[[1rb2]], [[1rx2]], [[1ra2]], [[3ql3]], [[4kjj]], [[4kjk]], [[4nx6]], [[4nx7]], [[4pss]], [[4pst]], [[4psy]], [[4pth]], [[4ptj]], [[4rgc]], [[4x5f]], [[4x5g]], [[4x5h]], [[4x5i]], [[4x5j]], [[1dyl]], [[7d3z]], [[7d49]], [[7d4l]], [[7d4x]], [[7d6g]], [[7lvc]] - EcDHFR+folate +NADP<br /> |
**[[4pdj]] - EcDHFR+folate+NADP – Neutron<br /> | **[[4pdj]] - EcDHFR+folate+NADP – Neutron<br /> | ||
**[[5cc9]], [[5ccc]], [[1rc4]], [[1dyj]], [[1dyh]], [[1rx6]], [[6cyv]] - EcDHFR+folate derivative +NADP <br /> | **[[5cc9]], [[5ccc]], [[1rc4]], [[1dyj]], [[1dyh]], [[1rx6]], [[6cyv]] - EcDHFR+folate derivative +NADP <br /> | ||
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**[[3tqb]] – CbDHFR + NADPH + folate<br /> | **[[3tqb]] – CbDHFR + NADPH + folate<br /> | ||
**[[3frd]] – SaDHFR (mutant)+folate +NADP<br /> | **[[3frd]] – SaDHFR (mutant)+folate +NADP<br /> | ||
| + | **[[6nnd]] - MtDHFR + DHF +NADPH<br /> | ||
*DHFR+co-factors | *DHFR+co-factors | ||
| + | **[[4m6j]] - hDHFR +NADPH<br /> | ||
| + | **[[8dfr]] - cDHFR +NADPH<BR /> | ||
**[[2hqp]], [[2lf1]] – LcDHFR+NADPH – NMR<BR /> | **[[2hqp]], [[2lf1]] – LcDHFR+NADPH – NMR<BR /> | ||
**[[2rk2]], [[2p4t]], [[1ra9]], [[1rx9]] – EcDHFR+NADP<br /> | **[[2rk2]], [[2p4t]], [[1ra9]], [[1rx9]] – EcDHFR+NADP<br /> | ||
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**[[6dfr]] - EcDHFR+NAP+NADP<br /> | **[[6dfr]] - EcDHFR+NAP+NADP<br /> | ||
**[[1dg8]], [[4kl9]] - MtDHFR +NADPH<BR /> | **[[1dg8]], [[4kl9]] - MtDHFR +NADPH<BR /> | ||
| - | **[[8dfr]] - cDHFR +NADPH<BR /> | ||
**[[3tqa]] – CbDHFR + NADPH<br /> | **[[3tqa]] – CbDHFR + NADPH<br /> | ||
| - | **[[4m6j]] - hDHFR +NADPH<br /> | ||
**[[2xw7]] - DHFR +NADPH – ''Mycobacterium smegmatis''<br /> | **[[2xw7]] - DHFR +NADPH – ''Mycobacterium smegmatis''<br /> | ||
**[[4m7u]] - EfDHFR +NADPH <br /> | **[[4m7u]] - EfDHFR +NADPH <br /> | ||
Current revision
3D Structures of Dihydrofolate reductase
Updated on 28-June-2021
