Ester protein crosslinks
From Proteopedia
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[https://en.wikipedia.org/wiki/Ester Ester bonds] between threonine and glutamine sidechains can form covalent cross-links between polypeptide chains<ref name="kwon2014">PMID: 24344302</ref>. First observed in repetitive domains of a putative surface-anchored adhesin of ''Clostridium perfringens'' (Gram positive)<ref name="kwon2014" />, analysis of sequences suggested "that these intramolecular ester bonds are a widespread and common feature of cell surface adhesion proteins in Gram-positive bacteria"<ref name="kwon2014" />. | [https://en.wikipedia.org/wiki/Ester Ester bonds] between threonine and glutamine sidechains can form covalent cross-links between polypeptide chains<ref name="kwon2014">PMID: 24344302</ref>. First observed in repetitive domains of a putative surface-anchored adhesin of ''Clostridium perfringens'' (Gram positive)<ref name="kwon2014" />, analysis of sequences suggested "that these intramolecular ester bonds are a widespread and common feature of cell surface adhesion proteins in Gram-positive bacteria"<ref name="kwon2014" />. | ||
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| + | ==Examples== | ||
| + | * [[4ni6]] REPEAT DOMAIN 1 OF CLOSTRIDIUM PERFRINGENS CPE0147 | ||
| + | * [[4mkm]] REPEAT DOMAINS 1 & 2 OF CLOSTRIDIUM PERFRINGENS CPE0147 | ||
==References== | ==References== | ||
<references /> | <references /> | ||
Revision as of 23:28, 30 June 2021
Ester bonds between threonine and glutamine sidechains can form covalent cross-links between polypeptide chains[1]. First observed in repetitive domains of a putative surface-anchored adhesin of Clostridium perfringens (Gram positive)[1], analysis of sequences suggested "that these intramolecular ester bonds are a widespread and common feature of cell surface adhesion proteins in Gram-positive bacteria"[1].
Examples
- 4ni6 REPEAT DOMAIN 1 OF CLOSTRIDIUM PERFRINGENS CPE0147
- 4mkm REPEAT DOMAINS 1 & 2 OF CLOSTRIDIUM PERFRINGENS CPE0147
References
- ↑ 1.0 1.1 1.2 Kwon H, Squire CJ, Young PG, Baker EN. Autocatalytically generated Thr-Gln ester bond cross-links stabilize the repetitive Ig-domain shaft of a bacterial cell surface adhesin. Proc Natl Acad Sci U S A. 2013 Dec 16. PMID:24344302 doi:http://dx.doi.org/10.1073/pnas.1316855111
