2r42

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==The Biochemical and Structural Basis for feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism==
==The Biochemical and Structural Basis for feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism==
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<StructureSection load='2r42' size='340' side='right' caption='[[2r42]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='2r42' size='340' side='right'caption='[[2r42]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2r42]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R42 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2r42]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R42 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FPS:S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]+TRIHYDROGEN+THIODIPHOSPHATE'>FPS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPS:S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]+TRIHYDROGEN+THIODIPHOSPHATE'>FPS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2r3v|2r3v]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2r3v|2r3v]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mvk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mvk ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mevalonate_kinase Mevalonate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.36 2.7.1.36] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Mevalonate_kinase Mevalonate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.36 2.7.1.36] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r42 OCA], [http://pdbe.org/2r42 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r42 RCSB], [http://www.ebi.ac.uk/pdbsum/2r42 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2r42 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r42 OCA], [https://pdbe.org/2r42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r42 RCSB], [https://www.ebi.ac.uk/pdbsum/2r42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r42 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/KIME_RAT KIME_RAT]] Note=Mutation in the mevalonate kinase gene causes mevalonicaciduria.
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[[https://www.uniprot.org/uniprot/KIME_RAT KIME_RAT]] Note=Mutation in the mevalonate kinase gene causes mevalonicaciduria.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KIME_RAT KIME_RAT]] May be a regulatory site in cholesterol biosynthetic pathway.
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[[https://www.uniprot.org/uniprot/KIME_RAT KIME_RAT]] May be a regulatory site in cholesterol biosynthetic pathway.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 2r42" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2r42" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Mevalonate kinase|Mevalonate kinase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Mevalonate kinase]]
[[Category: Mevalonate kinase]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]

Revision as of 04:13, 2 July 2021

The Biochemical and Structural Basis for feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism

PDB ID 2r42

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