1eqx

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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eqx OCA], [http://www.ebi.ac.uk/pdbsum/1eqx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1eqx RCSB]</span>
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'''SOLUTION STRUCTURE DETERMINATION AND MUTATIONAL ANALYSIS OF THE PAPILLOMAVIRUS E6-INTERACTING PEPTIDE OF E6AP'''
'''SOLUTION STRUCTURE DETERMINATION AND MUTATIONAL ANALYSIS OF THE PAPILLOMAVIRUS E6-INTERACTING PEPTIDE OF E6AP'''
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[[Category: Chen, J J.]]
[[Category: Chen, J J.]]
[[Category: Hong, Y.]]
[[Category: Hong, Y.]]
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[[Category: alpha helix]]
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[[Category: Alpha helix]]
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[[Category: peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:25:26 2008''
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Revision as of 12:25, 2 May 2008

Image:1eqx.jpg

Template:STRUCTURE 1eqx

SOLUTION STRUCTURE DETERMINATION AND MUTATIONAL ANALYSIS OF THE PAPILLOMAVIRUS E6-INTERACTING PEPTIDE OF E6AP


Overview

E6AP is a cellular protein that binds cancer-related papillomaviral E6 proteins. The E6 binding domain, called E6ap, is located on an 18-amino acid segment of E6AP. The corresponding peptide was synthesized and its structure determined by nuclear magnetic resonance spectroscopy. The overall structure of the peptide is helical. A consensus E6-binding sequence among different E6 interacting proteins contains three conserved hydrophobic residues. In the structure of the E6AP peptide, the three conserved leucines (Leu 9, Leu 12, and Leu 13) form a hydrophobic patch on one face of the alpha-helix. Substitution of any of these leucines with alanine abolished binding to E6 protein, indicating that the entire hydrophobic patch is necessary. Mutation of a glutamate to proline, but not alanine, also disrupted the interaction between E6 and E6AP protein, suggesting that the E6-binding motif of the E6AP protein must be helical when bound to E6. Comparison of the E6ap structure and mutational results with those of another E6-binding protein (E6BP/ERC-55) indicates the existence of a general E6-binding motif.

About this Structure

1EQX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure determination and mutational analysis of the papillomavirus E6 interacting peptide of E6AP., Be X, Hong Y, Wei J, Androphy EJ, Chen JJ, Baleja JD, Biochemistry. 2001 Feb 6;40(5):1293-9. PMID:11170455 Page seeded by OCA on Fri May 2 15:25:26 2008

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