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1esl

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[[Image:1esl.gif|left|200px]]
[[Image:1esl.gif|left|200px]]
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{{Structure
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|PDB= 1esl |SIZE=350|CAPTION= <scene name='initialview01'>1esl</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1esl", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>
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{{STRUCTURE_1esl| PDB=1esl | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1esl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1esl OCA], [http://www.ebi.ac.uk/pdbsum/1esl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1esl RCSB]</span>
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'''INSIGHT INTO E-SELECTIN(SLASH)LIGAND INTERACTION FROM THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THE LEC(SLASH)EGF DOMAINS'''
'''INSIGHT INTO E-SELECTIN(SLASH)LIGAND INTERACTION FROM THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THE LEC(SLASH)EGF DOMAINS'''
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[[Category: Crowther, R L.]]
[[Category: Crowther, R L.]]
[[Category: Graves, B J.]]
[[Category: Graves, B J.]]
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[[Category: cell adhesion protein]]
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[[Category: Cell adhesion protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:28:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:08:47 2008''
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Revision as of 12:28, 2 May 2008

Image:1esl.gif

Template:STRUCTURE 1esl

INSIGHT INTO E-SELECTIN(SLASH)LIGAND INTERACTION FROM THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THE LEC(SLASH)EGF DOMAINS


Overview

The three-dimensional structure of the ligand-binding region of human E-selectin has been determined at 2.0 A resolution. The structure reveals limited contact between the two domains and a coordination of Ca2+ not predicted from other C-type lectins. Structure/function analysis indicates a defined region and specific amino-acid side chains that may be involved in ligand binding. These features of the E-selectin/ligand interaction have important implications for understanding the recruitment of leukocytes to sites of inflammation.

About this Structure

1ESL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains., Graves BJ, Crowther RL, Chandran C, Rumberger JM, Li S, Huang KS, Presky DH, Familletti PC, Wolitzky BA, Burns DK, Nature. 1994 Feb 10;367(6463):532-8. PMID:7509040 Page seeded by OCA on Fri May 2 15:28:21 2008

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