7a6u
From Proteopedia
(Difference between revisions)
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==Cryo-EM structure of the cytoplasmic domain of human TRPC6== | ==Cryo-EM structure of the cytoplasmic domain of human TRPC6== | ||
| - | <StructureSection load='7a6u' size='340' side='right'caption='[[7a6u]]' scene=''> | + | <StructureSection load='7a6u' size='340' side='right'caption='[[7a6u]], [[Resolution|resolution]] 3.62Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A6U OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[7a6u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A6U FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRPC6, TRP6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a6u OCA], [https://pdbe.org/7a6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a6u RCSB], [https://www.ebi.ac.uk/pdbsum/7a6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a6u ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/TRPC6_HUMAN TRPC6_HUMAN]] Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/TRPC6_HUMAN TRPC6_HUMAN]] Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion.<ref>PMID:19936226</ref> <ref>PMID:23291369</ref> <ref>PMID:26892346</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Bountra C]] | + | [[Category: Bountra, C]] |
| - | [[Category: Burgess-Brown | + | [[Category: Burgess-Brown, N A]] |
| - | [[Category: Carpenter | + | [[Category: Carpenter, E P]] |
| - | [[Category: Chalk R]] | + | [[Category: Chalk, R]] |
| - | [[Category: Edwards | + | [[Category: Edwards, A M]] |
| - | [[Category: Grieben M]] | + | [[Category: Grieben, M]] |
| - | [[Category: Marsden | + | [[Category: Marsden, B D]] |
| - | [[Category: Mukhopadhyay | + | [[Category: Mukhopadhyay, S M.M]] |
| - | [[Category: Pike | + | [[Category: Pike, A C.W]] |
| - | [[Category: Wang D]] | + | [[Category: Structural genomic]] |
| + | [[Category: Wang, D]] | ||
| + | [[Category: Ion transport protein transient receptor ion channel ii]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Sgc]] | ||
Revision as of 10:10, 7 July 2021
Cryo-EM structure of the cytoplasmic domain of human TRPC6
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Categories: Human | Large Structures | Arrowsmith, C H | Bountra, C | Burgess-Brown, N A | Carpenter, E P | Chalk, R | Edwards, A M | Grieben, M | Marsden, B D | Mukhopadhyay, S M.M | Pike, A C.W | Structural genomic | Wang, D | Ion transport protein transient receptor ion channel ii | Membrane protein | Sgc
