7ngp
From Proteopedia
(Difference between revisions)
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==D1-state of wild type human mitochondrial LONP1 protease== | ==D1-state of wild type human mitochondrial LONP1 protease== | ||
| - | <StructureSection load='7ngp' size='340' side='right'caption='[[7ngp]]' scene=''> | + | <StructureSection load='7ngp' size='340' side='right'caption='[[7ngp]], [[Resolution|resolution]] 15.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NGP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NGP FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7ngp]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NGP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NGP FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ngp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ngp OCA], [https://pdbe.org/7ngp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ngp RCSB], [https://www.ebi.ac.uk/pdbsum/7ngp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ngp ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr> |
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7ngq|7ngq]], [[7ngl|7ngl]], [[7ngf|7ngf]], [[7ngc|7ngc]], [[7ng5|7ng5]], [[7ng4|7ng4]]</div></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LONP1, PRSS15 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Endopeptidase_La Endopeptidase La], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.53 3.4.21.53] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ngp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ngp OCA], [https://pdbe.org/7ngp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ngp RCSB], [https://www.ebi.ac.uk/pdbsum/7ngp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ngp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/LONM_HUMAN LONM_HUMAN]] ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein.[HAMAP-Rule:MF_03120]<ref>PMID:12198491</ref> <ref>PMID:15870080</ref> <ref>PMID:17420247</ref> <ref>PMID:8248235</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Endopeptidase La]] | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Abrahams | + | [[Category: Abrahams, J P]] |
| - | [[Category: Maier T]] | + | [[Category: Maier, T]] |
| - | [[Category: Mohammed I]] | + | [[Category: Mohammed, I]] |
| - | [[Category: Schenck N]] | + | [[Category: Schenck, N]] |
| - | [[Category: Schmitz | + | [[Category: Schmitz, K A]] |
| + | [[Category: Human mitochondrial aaa+ protease]] | ||
| + | [[Category: Motor protein]] | ||
Revision as of 10:17, 7 July 2021
D1-state of wild type human mitochondrial LONP1 protease
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