7nur

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==Structure of the Toxoplasma gondii kinase Ron13, kinase-dead mutant==
==Structure of the Toxoplasma gondii kinase Ron13, kinase-dead mutant==
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<StructureSection load='7nur' size='340' side='right'caption='[[7nur]]' scene=''>
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<StructureSection load='7nur' size='340' side='right'caption='[[7nur]], [[Resolution|resolution]] 3.12&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NUR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7nur]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxgg Toxgg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NUR FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nur OCA], [https://pdbe.org/7nur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nur RCSB], [https://www.ebi.ac.uk/pdbsum/7nur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nur ProSAT]</span></td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TGGT1_321650 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=507601 TOXGG])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nur OCA], [https://pdbe.org/7nur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nur RCSB], [https://www.ebi.ac.uk/pdbsum/7nur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nur ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Active host cell invasion by the obligate intracellular apicomplexan parasites relies on the formation of a moving junction, which connects parasite and host cell plasma membranes during entry. Invading Toxoplasma gondii tachyzoites secrete their rhoptry content and insert a complex of RON proteins on the cytoplasmic side of the host cell membrane providing an anchor to which the parasite tethers. Here we show that a rhoptry-resident kinase RON13 is a key virulence factor that plays a crucial role in host cell entry. Cryo-EM, kinase assays, phosphoproteomics and cellular analyses reveal that RON13 is a secretory pathway kinase of atypical structure that phosphorylates rhoptry proteins including the components of the RON complex. Ultimately, RON13 kinase activity controls host cell invasion by anchoring the moving junction at the parasite-host cell interface.
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Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion.,Lentini G, Ben Chaabene R, Vadas O, Ramakrishnan C, Mukherjee B, Mehta V, Lunghi M, Grossmann J, Maco B, Visentin R, Hehl AB, Korkhov VM, Soldati-Favre D Nat Commun. 2021 Jun 18;12(1):3788. doi: 10.1038/s41467-021-24083-y. PMID:34145271<ref>PMID:34145271</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7nur" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Korkhov VM]]
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[[Category: Toxgg]]
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[[Category: Mehta V]]
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[[Category: Korkhov, V M]]
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[[Category: Mehta, V]]
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[[Category: Kinase]]
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[[Category: Secretory pathway]]
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[[Category: Transferase]]

Revision as of 10:18, 7 July 2021

Structure of the Toxoplasma gondii kinase Ron13, kinase-dead mutant

PDB ID 7nur

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