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2v0n

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<StructureSection load='2v0n' size='340' side='right'caption='[[2v0n]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
<StructureSection load='2v0n' size='340' side='right'caption='[[2v0n]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2v0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cauvc Cauvc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V0N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2v0n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cauvc Cauvc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V0N FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAV:GUANOSINE-5-RP-ALPHA-THIO-TRIPHOSPHATE'>GAV</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAV:GUANOSINE-5-RP-ALPHA-THIO-TRIPHOSPHATE'>GAV</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1w25|1w25]], [[2wb4|2wb4]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1w25|1w25]], [[2wb4|2wb4]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0n OCA], [http://pdbe.org/2v0n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v0n RCSB], [http://www.ebi.ac.uk/pdbsum/2v0n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v0n ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0n OCA], [https://pdbe.org/2v0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v0n RCSB], [https://www.ebi.ac.uk/pdbsum/2v0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v0n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PLED_CAUCR PLED_CAUCR]] Response regulator that is part of a signal transduction pathway controlling cell differentiation in the swarmer-to-stalked cell transition (By similarity). Catalyzes the condensation of two GTP molecules to the cyclic dinucleotide di-GMP (c-di-GMP), which acts as a secondary messenger (By similarity).
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[[https://www.uniprot.org/uniprot/PLED_CAUCR PLED_CAUCR]] Response regulator that is part of a signal transduction pathway controlling cell differentiation in the swarmer-to-stalked cell transition (By similarity). Catalyzes the condensation of two GTP molecules to the cyclic dinucleotide di-GMP (c-di-GMP), which acts as a secondary messenger (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[C-di-GMP|C-di-GMP]]
 
*[[Diguanylate cyclase|Diguanylate cyclase]]
*[[Diguanylate cyclase|Diguanylate cyclase]]
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*[[PleD activation|PleD activation]]
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*[[Response regulator 3D structure|Response regulator 3D structure]]
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*[[PleD allosteric product inhibition|PleD allosteric product inhibition]]
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*[[PleD catalysis|PleD catalysis]]
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*[[Response regulator|Response regulator]]
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*[[Response regulator PLED in complex with C-di-GMP|Response regulator PLED in complex with C-di-GMP]]
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== References ==
== References ==
<references/>
<references/>

Revision as of 10:40, 7 July 2021

ACTIVATED RESPONSE REGULATOR PLED IN COMPLEX WITH C-DIGMP AND GTP- ALPHA-S

PDB ID 2v0n

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