This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2w6c
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==ACHE IN COMPLEX WITH A BIS-(-)-NOR-MEPTAZINOL DERIVATIVE== | ==ACHE IN COMPLEX WITH A BIS-(-)-NOR-MEPTAZINOL DERIVATIVE== | ||
| - | <StructureSection load='2w6c' size='340' side='right' caption='[[2w6c]], [[Resolution|resolution]] 2.69Å' scene=''> | + | <StructureSection load='2w6c' size='340' side='right'caption='[[2w6c]], [[Resolution|resolution]] 2.69Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2w6c]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2w6c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W6C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W6C FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BM4:3-[(3R)-3-ETHYL-1-{9-[(3S)-3-ETHYL-3-(3-HYDROXYPHENYL)AZEPAN-1-YL]NONYL}AZEPAN-3-YL]PHENOL'>BM4</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BM4:3-[(3R)-3-ETHYL-1-{9-[(3S)-3-ETHYL-3-(3-HYDROXYPHENYL)AZEPAN-1-YL]NONYL}AZEPAN-3-YL]PHENOL'>BM4</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zgb|1zgb]], [[1amn|1amn]], [[1qti|1qti]], [[1e66|1e66]], [[2vq6|2vq6]], [[2ack|2ack]], [[2j3d|2j3d]], [[1qii|1qii]], [[2ckm|2ckm]], [[1dx6|1dx6]], [[1qij|1qij]], [[1qie|1qie]], [[1acl|1acl]], [[1w4l|1w4l]], [[1odc|1odc]], [[2cmf|2cmf]], [[2j3q|2j3q]], [[1gqs|1gqs]], [[1e3q|1e3q]], [[2j4f|2j4f]], [[2dfp|2dfp]], [[1qik|1qik]], [[2c5f|2c5f]], [[1ea5|1ea5]], [[2vjc|2vjc]], [[1qif|1qif]], [[1eea|1eea]], [[2vjb|2vjb]], [[1qig|1qig]], [[1qid|1qid]], [[1zgc|1zgc]], [[1jjb|1jjb]], [[2vjd|2vjd]], [[1ut6|1ut6]], [[2vt6|2vt6]], [[2vt7|2vt7]], [[2cek|2cek]], [[1qim|1qim]], [[1gpk|1gpk]], [[1jga|1jga]], [[3ace|3ace]], [[1w6r|1w6r]], [[1oce|1oce]], [[1som|1som]], [[1vxo|1vxo]], [[2vja|2vja]], [[1cfj|1cfj]], [[2v96|2v96]], [[1u65|1u65]], [[1w76|1w76]], [[1ax9|1ax9]], [[1h22|1h22]], [[1eve|1eve]], [[2c4h|2c4h]], [[2ace|2ace]], [[2va9|2va9]], [[1gqr|1gqr]], [[1vxr|1vxr]], [[4ace|4ace]], [[2c58|2c58]], [[1hbj|1hbj]], [[1w75|1w75]], [[1vot|1vot]], [[2c5g|2c5g]], [[1jgb|1jgb]], [[2v98|2v98]], [[1gpn|1gpn]], [[1qih|1qih]], [[1h23|1h23]], [[1acj|1acj]], [[1fss|1fss]], [[2v97|2v97]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zgb|1zgb]], [[1amn|1amn]], [[1qti|1qti]], [[1e66|1e66]], [[2vq6|2vq6]], [[2ack|2ack]], [[2j3d|2j3d]], [[1qii|1qii]], [[2ckm|2ckm]], [[1dx6|1dx6]], [[1qij|1qij]], [[1qie|1qie]], [[1acl|1acl]], [[1w4l|1w4l]], [[1odc|1odc]], [[2cmf|2cmf]], [[2j3q|2j3q]], [[1gqs|1gqs]], [[1e3q|1e3q]], [[2j4f|2j4f]], [[2dfp|2dfp]], [[1qik|1qik]], [[2c5f|2c5f]], [[1ea5|1ea5]], [[2vjc|2vjc]], [[1qif|1qif]], [[1eea|1eea]], [[2vjb|2vjb]], [[1qig|1qig]], [[1qid|1qid]], [[1zgc|1zgc]], [[1jjb|1jjb]], [[2vjd|2vjd]], [[1ut6|1ut6]], [[2vt6|2vt6]], [[2vt7|2vt7]], [[2cek|2cek]], [[1qim|1qim]], [[1gpk|1gpk]], [[1jga|1jga]], [[3ace|3ace]], [[1w6r|1w6r]], [[1oce|1oce]], [[1som|1som]], [[1vxo|1vxo]], [[2vja|2vja]], [[1cfj|1cfj]], [[2v96|2v96]], [[1u65|1u65]], [[1w76|1w76]], [[1ax9|1ax9]], [[1h22|1h22]], [[1eve|1eve]], [[2c4h|2c4h]], [[2ace|2ace]], [[2va9|2va9]], [[1gqr|1gqr]], [[1vxr|1vxr]], [[4ace|4ace]], [[2c58|2c58]], [[1hbj|1hbj]], [[1w75|1w75]], [[1vot|1vot]], [[2c5g|2c5g]], [[1jgb|1jgb]], [[2v98|2v98]], [[1gpn|1gpn]], [[1qih|1qih]], [[1h23|1h23]], [[1acj|1acj]], [[1fss|1fss]], [[2v97|2v97]]</div></td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w6c OCA], [https://pdbe.org/2w6c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w6c RCSB], [https://www.ebi.ac.uk/pdbsum/2w6c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w6c ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ACES_TORCA ACES_TORCA]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w6/2w6c_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w6/2w6c_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 32: | Line 32: | ||
==See Also== | ==See Also== | ||
| - | *[[Acetylcholinesterase | + | *[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]] |
| - | + | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 39: | Line 38: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Acetylcholinesterase]] | [[Category: Acetylcholinesterase]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Torpedo californica]] | [[Category: Torpedo californica]] | ||
[[Category: Fu, W]] | [[Category: Fu, W]] | ||
| Line 48: | Line 48: | ||
[[Category: Tang, Y]] | [[Category: Tang, Y]] | ||
[[Category: Xie, Q]] | [[Category: Xie, Q]] | ||
| + | [[Category: Alternative splicing]] | ||
[[Category: Alzheimer's disease]] | [[Category: Alzheimer's disease]] | ||
[[Category: Catalytic triad]] | [[Category: Catalytic triad]] | ||
Revision as of 10:52, 7 July 2021
ACHE IN COMPLEX WITH A BIS-(-)-NOR-MEPTAZINOL DERIVATIVE
| |||||||||||
Categories: Acetylcholinesterase | Large Structures | Torpedo californica | Fu, W | Greenblatt, H M | Paz, A | Qiu, Z | Silman, I | Sussman, J L | Tang, Y | Xie, Q | Alternative splicing | Alzheimer's disease | Catalytic triad | Cell junction | Cell membrane | Cholinesterase | Glycoprotein | Gpi-anchor | Hydrolase | Membrane | Neurotransmitter degradation | Serine esterase | Serine hydrolase
