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1bc7
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(New page: 200px<br /> <applet load="1bc7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bc7, resolution 2.01Å" /> '''SERUM RESPONSE FACT...)
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Revision as of 14:01, 12 November 2007
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SERUM RESPONSE FACTOR ACCESSORY PROTEIN 1A (SAP-1)/DNA COMPLEX
Overview
SAP-1 is a member of the Ets transcription factors and cooperates with SRF, protein to activate transcription of the c-fos protooncogene. The crystal, structures of the conserved ETS domain of SAP-1 bound to DNA sequences, from the E74 and c-fos promoters reveal that a set of conserved residues, contact a GGA core DNA sequence. Discrimination for sequences outside this, core is mediated by DNA contacts from conserved and nonconserved protein, residues and sequence-dependent DNA structural properties characteristic, of A-form DNA structure. Comparison with the related PU.1/DNA and, GABPalpha/beta/DNA complexes provides general insights into DNA, discrimination between Ets proteins. Modeling studies of a SAP-1/SRF/DNA, complex suggest that SRF may modulate SAP-1 binding to DNA by interacting, with its ETS domain.
About this Structure
1BC7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins., Mo Y, Vaessen B, Johnston K, Marmorstein R, Mol Cell. 1998 Aug;2(2):201-12. PMID:9734357
Page seeded by OCA on Mon Nov 12 16:08:21 2007
