1ete

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[[Image:1ete.gif|left|200px]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ete FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ete OCA], [http://www.ebi.ac.uk/pdbsum/1ete PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ete RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE FLT3 LIGAND'''
'''CRYSTAL STRUCTURE OF THE FLT3 LIGAND'''
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[[Category: Savvides, S N.]]
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[[Category: Four-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:29:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Apr 7 20:44:50 2008''
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Revision as of 12:29, 2 May 2008

Image:1ete.gif

Template:STRUCTURE 1ete

CRYSTAL STRUCTURE OF THE FLT3 LIGAND


Overview

Human Flt3 ligand (Flt3L) stimulates early hematopoiesis by activating a type III tyrosine kinase receptor on primitive bone marrow stem cells. The crystal structure of soluble Flt3L reveals that it is a homodimer of two short chain alpha-helical bundles. Comparisons of structure-function relationships of Flt3L with the homologous hematopoietic cytokines macrophage colony stimulating factor (MCSF) and stem cell factor (SCF) suggest that they have a common receptor binding mode that is distinct from the paradigm derived from the complex of growth hormone with its receptor. Furthermore, we identify recognition features common to all helical and cystine-knot protein ligands that activate type III tyrosine kinase receptors, and the closely related type V tyrosine kinase receptors.

About this Structure

1ETE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots., Savvides SN, Boone T, Andrew Karplus P, Nat Struct Biol. 2000 Jun;7(6):486-91. PMID:10881197 Page seeded by OCA on Fri May 2 15:29:54 2008

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