1etg
From Proteopedia
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'''REV RESPONSE ELEMENT (RRE) RNA COMPLEXED WITH REV PEPTIDE, NMR, 19 STRUCTURES''' | '''REV RESPONSE ELEMENT (RRE) RNA COMPLEXED WITH REV PEPTIDE, NMR, 19 STRUCTURES''' | ||
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[[Category: Tan, R.]] | [[Category: Tan, R.]] | ||
[[Category: Willamson, J R.]] | [[Category: Willamson, J R.]] | ||
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| - | + | [[Category: Mrna splicing]] | |
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Revision as of 12:30, 2 May 2008
REV RESPONSE ELEMENT (RRE) RNA COMPLEXED WITH REV PEPTIDE, NMR, 19 STRUCTURES
Overview
The solution structure of a human immunodeficiency virus type-1 (HIV-1) Rev peptide bound to stem-loop IIB of the Rev response element (RRE) RNA was solved by nuclear magnetic resonance spectroscopy. The Rev peptide has an alpha-helical conformation and binds in the major groove of the RNA near a purine-rich internal loop. Several arginine side chains make base-specific contacts, and an asparagine residue contacts a G.A base pair. The phosphate backbone adjacent to a G.G base pair adopts an unusual structure that allows the peptide to access a widened major groove. The structure formed by the two purine-purine base pairs of the RRE creates a distinctive binding pocket that the peptide can use for specific recognition.
About this Structure
1ETG is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
Alpha helix-RNA major groove recognition in an HIV-1 rev peptide-RRE RNA complex., Battiste JL, Mao H, Rao NS, Tan R, Muhandiram DR, Kay LE, Frankel AD, Williamson JR, Science. 1996 Sep 13;273(5281):1547-51. PMID:8703216 Page seeded by OCA on Fri May 2 15:30:01 2008
