1euj

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[[Image:1euj.gif|left|200px]]
[[Image:1euj.gif|left|200px]]
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{{Structure
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|PDB= 1euj |SIZE=350|CAPTION= <scene name='initialview01'>1euj</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1euj", creates the "Structure Box" on the page.
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{{STRUCTURE_1euj| PDB=1euj | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1euj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1euj OCA], [http://www.ebi.ac.uk/pdbsum/1euj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1euj RCSB]</span>
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'''A NOVEL ANTI-TUMOR CYTOKINE CONTAINS A RNA-BINDING MOTIF PRESENT IN AMINOACYL-TRNA SYNTHETASES'''
'''A NOVEL ANTI-TUMOR CYTOKINE CONTAINS A RNA-BINDING MOTIF PRESENT IN AMINOACYL-TRNA SYNTHETASES'''
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[[Category: Li, R.]]
[[Category: Li, R.]]
[[Category: Shin, J.]]
[[Category: Shin, J.]]
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[[Category: apoptosis]]
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[[Category: Apoptosis]]
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[[Category: cytokine]]
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[[Category: Cytokine]]
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[[Category: emap 2]]
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[[Category: Emap 2]]
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[[Category: emap ii]]
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[[Category: Emap ii]]
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[[Category: rna binding motif]]
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[[Category: Rna binding motif]]
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[[Category: trna synthetase]]
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[[Category: Trna synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:32:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:09:52 2008''
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Revision as of 12:32, 2 May 2008

Image:1euj.gif

Template:STRUCTURE 1euj

A NOVEL ANTI-TUMOR CYTOKINE CONTAINS A RNA-BINDING MOTIF PRESENT IN AMINOACYL-TRNA SYNTHETASES


Overview

Endothelial monocyte-activating polypeptide II (EMAP II) is a novel pro-apoptotic cytokine that shares sequence homology with the C-terminal regions of several tRNA synthetases. Pro-EMAP II, the precursor of EMAP II, is associated with the multi-tRNA synthetase complex and facilitates aminoacylation activity. The structure of human EMAP II, solved at 1.8 A resolution, revealed the oligomer-binding fold for binding different tRNAs and a domain that is structurally homologous to other chemokines. The similar structures to the RNA binding motif of EMAP II was previously observed in the anticodon binding domain of yeast Asp-tRNA synthetase (AspRSSC) and the B2 domain of Thermus thermophilus Phe-tRNA synthetase. The RNA binding pattern of EMAP II is likely to be nonspecific, in contrast to the AspRSSC. The peptide sequence that is responsible for cytokine activity is located, for the most part, in the beta1 strand. It is divided into two regions by a neighboring loop.

About this Structure

1EUJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A novel anti-tumor cytokine contains an RNA binding motif present in aminoacyl-tRNA synthetases., Kim Y, Shin J, Li R, Cheong C, Kim K, Kim S, J Biol Chem. 2000 Sep 1;275(35):27062-8. PMID:10852899 Page seeded by OCA on Fri May 2 15:32:01 2008

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