7awz
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7awz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7awz OCA], [https://pdbe.org/7awz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7awz RCSB], [https://www.ebi.ac.uk/pdbsum/7awz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7awz ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7awz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7awz OCA], [https://pdbe.org/7awz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7awz RCSB], [https://www.ebi.ac.uk/pdbsum/7awz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7awz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Recent years have seen an increase in the development of computational proteins, including symmetric ones. A ninefold-symmetric beta-propeller protein named Cake has recently been developed. Here, attempts were made to further engineer this protein into a threefold-symmetric nine-bladed propeller using computational design. Two nine-bladed propeller proteins were designed, named Scone-E and Scone-R. Crystallography, however, revealed the structure of both designs to adopt an eightfold conformation with distorted termini, leading to a pseudo-symmetric protein. One of the proteins could only be crystallized upon the addition of a polyoxometalate, highlighting the usefulness of these molecules as crystallization additives. | ||
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| + | Crystal structures of Scone: pseudosymmetric folding of a symmetric designer protein.,Mylemans B, Killian T, Vandebroek L, Van Meervelt L, Tame JRH, Parac-Vogt TN, Voet ARD Acta Crystallogr D Struct Biol. 2021 Jul 1;77(Pt 7):933-942. doi:, 10.1107/S2059798321005787. Epub 2021 Jun 18. PMID:34196619<ref>PMID:34196619</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7awz" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 10:04, 14 July 2021
Crystal structure of the computationally designed Scone-E protein
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