7nt8
From Proteopedia
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==Influenza virus H3N2 nucleoprotein - R416A mutant== | ==Influenza virus H3N2 nucleoprotein - R416A mutant== | ||
| - | <StructureSection load='7nt8' size='340' side='right'caption='[[7nt8]]' scene=''> | + | <StructureSection load='7nt8' size='340' side='right'caption='[[7nt8]], [[Resolution|resolution]] 2.22Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NT8 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7nt8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NT8 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nt8 OCA], [https://pdbe.org/7nt8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nt8 RCSB], [https://www.ebi.ac.uk/pdbsum/7nt8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nt8 ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6182 Blood fluke])</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nt8 OCA], [https://pdbe.org/7nt8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nt8 RCSB], [https://www.ebi.ac.uk/pdbsum/7nt8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nt8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/GST26_SCHJA GST26_SCHJA]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Influenza A viruses of the H1N1 and H3N2 subtypes are responsible for seasonal epidemic events. The influenza nucleoprotein (NP) binds to the viral genomic RNA and is essential for its replication. Efforts are under way to produce therapeutics and vaccines targeting the NP. Despite this, no structure of an NP from an H3N2 virus has previously been determined. Here, the structure of the A/Northern Territory/60/1968 (H3N2) influenza virus NP is presented at 2.2 A resolution. The structure is highly similar to those of the A/WSN/1933 (H1N1) and A/Hong Kong/483/97 (H5N1) NPs. Nonconserved amino acids are widely dispersed both at the sequence and structural levels. A movement of the 73-90 RNA-binding loop is observed to be the key difference between the structure determined here and previous structures. The data presented here increase the understanding of structural conservation amongst influenza NPs and may aid in the design of universal interventions against influenza. | ||
| + | |||
| + | Structure of an H3N2 influenza virus nucleoprotein.,Knight ML, Fan H, Bauer DLV, Grimes JM, Fodor E, Keown JR Acta Crystallogr F Struct Biol Commun. 2021 Jul 1;77(Pt 7):208-214. doi:, 10.1107/S2053230X2100635X. Epub 2021 Jun 29. PMID:34196611<ref>PMID:34196611</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7nt8" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Blood fluke]] | ||
| + | [[Category: Glutathione transferase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Fodor E]] | + | [[Category: Fodor, E]] |
| - | [[Category: Grimes | + | [[Category: Grimes, J M]] |
| - | [[Category: Keown | + | [[Category: Keown, J R]] |
| - | [[Category: Knight | + | [[Category: Knight, M L]] |
| + | [[Category: Influenza virus]] | ||
| + | [[Category: Nucleoprotein]] | ||
| + | [[Category: Rna binding protein]] | ||
| + | [[Category: Rna-binding protein]] | ||
Revision as of 10:15, 14 July 2021
Influenza virus H3N2 nucleoprotein - R416A mutant
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