1ev0
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1ev0.jpg|left|200px]] | [[Image:1ev0.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1ev0", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_1ev0| PDB=1ev0 | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''SOLUTION STRUCTURE OF THE MINE TOPOLOGICAL SPECIFICITY DOMAIN''' | '''SOLUTION STRUCTURE OF THE MINE TOPOLOGICAL SPECIFICITY DOMAIN''' | ||
| Line 29: | Line 26: | ||
[[Category: Mullen, G P.]] | [[Category: Mullen, G P.]] | ||
[[Category: Pan, B.]] | [[Category: Pan, B.]] | ||
| - | [[Category: | + | [[Category: Cell division]] |
| - | [[Category: | + | [[Category: Mincd]] |
| - | [[Category: | + | [[Category: Mine]] |
| - | [[Category: | + | [[Category: Minicell]] |
| - | [[Category: | + | [[Category: Topological specificity]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:32:59 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 12:33, 2 May 2008
SOLUTION STRUCTURE OF THE MINE TOPOLOGICAL SPECIFICITY DOMAIN
Overview
Correct positioning of the division septum in Escherichia coli depends on the coordinated action of the MinC, MinD and MinE proteins. Topological specificity is conferred on the MinCD division inhibitor by MinE, which counters MinCD activity only in the vicinity of the preferred midcell division site. Here we report the structure of the homodimeric topological specificity domain of Escherichia coli MinE and show that it forms a novel alphabeta sandwich. Structure-directed mutagenesis of conserved surface residues has enabled us to identify a spatially restricted site on the surface of the protein that is critical for the topological specificity function of MinE.
About this Structure
1EV0 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Structural basis for the topological specificity function of MinE., King GF, Shih YL, Maciejewski MW, Bains NP, Pan B, Rowland SL, Mullen GP, Rothfield LI, Nat Struct Biol. 2000 Nov;7(11):1013-7. PMID:11062554 Page seeded by OCA on Fri May 2 15:32:59 2008
