Esterification

Esterification is a chemical reaction of an acid with an alcohol (R'OH) to form an ester (RCOOR').

Usually esterification refers to reaction between an organic (carboxylic) acid (RCOOH) with an alcohol (R'OH) to form an ester (RCOOR') and water and called Fischer esterification. The chemical reaction for Fischer esterification is given below:

The when the carboxylic acid accepts a proton from the strong acid catalyst.

In the the alcohol attacks the protonated carbonyl group to create a tetrahedral intermediate structure. In the a proton is lost at one oxygen atom and bonds to another oxygen atom. In the water molecule leaves the structure. In the .

An animated example of this reaction is shown. Please click on the buttons below to animate the reaction with different representations. Use the popup button to enlarge the view and the quality button to turn on anti-aliasing.

The animation was originally done by Prof. Dr. Verena Pietzner; for details, see her web site ChiLe^[1]. The implementation into Proteopedia was done by Prof. Jaime Prilusky, Prof. Joel L. Sussman

and Veronika Pelekhov.