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1bhd
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(New page: 200px<br /> <applet load="1bhd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bhd, resolution 2.0Å" /> '''SECOND CALPONIN HOMO...)
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Revision as of 14:03, 12 November 2007
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SECOND CALPONIN HOMOLOGY DOMAIN FROM UTROPHIN
Overview
Utrophin is a close homologue of dystrophin, the protein defective in, Duchenne muscular dystrophy. Like dystrophin, it is composed of three, regions: an N-terminal region that binds actin filaments, a large central, region with triple coiled-coil repeats, and a C-terminal region that, interacts with components in the dystroglycan protein complex at the, plasma membrane. The N-terminal actin-binding region consists of two, calponin homology domains and is related to the actin-binding domains of a, superfamily of proteins including alpha-actinin, spectrin and fimbrin., Here, we present the 2.0 A structure of the second calponin homology, domain of utrophin solved by X-ray crystallography, and compare it to the, other calponin homology domains previously determined from spectrin and, fimbrin.
About this Structure
1BHD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The 2.0 A structure of the second calponin homology domain from the actin-binding region of the dystrophin homologue utrophin., Keep NH, Norwood FL, Moores CA, Winder SJ, Kendrick-Jones J, J Mol Biol. 1999 Jan 22;285(3):1257-64. PMID:9887274
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