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Ferric-binding protein

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== Function ==
== Function ==
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The process of bacterial multiplication requires the acquisition of growth-essential nutrients including iron, from the host cell. '''Ferric-binding protein''' or '''iron binding protein''' (FBP) transfers iron across the periplasmic space from human transferrin to pathogenic bacteria<ref>PMID:7934822</ref>.
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The process of bacterial multiplication requires the acquisition of growth-essential nutrients including iron, from the host cell. '''Ferric-binding protein''' or '''iron binding protein''' or '''periplasmic iron binding protein'''(FBP) transfers iron across the periplasmic space from human transferrin to pathogenic bacteria<ref>PMID:7934822</ref>.
== Structural highlights ==
== Structural highlights ==

Revision as of 10:30, 25 July 2021

Ferric-binding protein complex with Fe+3 (orange) and phosphate ion (PDB code 3od7).

Drag the structure with the mouse to rotate

3D Structures of ferric-binding protein

Updated on 25-July-2021

1mrp, 3od7, 3odb – HiFBP + Fe – Haemophilus influenzae
1d9v – HiFBP
1nnf, 1qvs, 1qw0, 2o68, 2o69, 2o6a, 3kn7, 3kn8 - HiFBP (mutant) + Fe
1r1n – NgFBP + oxo-Fe – Neisseria gonorrhoeae
1xc1 – NgFBP + oxo-Zr
3tyh – NgFBP + oxo-Cu
1q35 – FBP – Mannheimia haemolytica
4elo, 4elp, 4elq – TtFBP – Thermus thermophilus
4elr – TtFBP + Fe
6iwf – PaFBP – Pseudomonas aeruginosa
6ivy – PaFBP + Fe
6j2s – PaFBP + Ga
6mfl – FBP + Fe + acinetobactin – Acinetobacter baumannii

References

  1. ↑ Chen CY, Berish SA, Morse SA, Mietzner TA. The ferric iron-binding protein of pathogenic Neisseria spp. functions as a periplasmic transport protein in iron acquisition from human transferrin. Mol Microbiol. 1993 Oct;10(2):311-8. PMID:7934822
  2. ↑ Khambati HK, Moraes TF, Singh J, Shouldice SR, Yu RH, Schryvers AB. The role of vicinal tyrosine residues in the function of Haemophilus influenzae ferric binding protein A. Biochem J. 2010 Aug 27. PMID:20799927 doi:10.1042/BJ20101043

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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