1exb

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[[Image:1exb.gif|left|200px]]
[[Image:1exb.gif|left|200px]]
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{{Structure
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{{STRUCTURE_1exb| PDB=1exb | SCENE= }}
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|RELATEDENTRY=[[1qrq|1qrq]], [[1t1d|1t1d]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1exb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1exb OCA], [http://www.ebi.ac.uk/pdbsum/1exb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1exb RCSB]</span>
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'''STRUCTURE OF THE CYTOPLASMIC BETA SUBUNIT-T1 ASSEMBLY OF VOLTAGE-DEPENDENT K CHANNELS'''
'''STRUCTURE OF THE CYTOPLASMIC BETA SUBUNIT-T1 ASSEMBLY OF VOLTAGE-DEPENDENT K CHANNELS'''
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[[Category: Mann, S.]]
[[Category: Mann, S.]]
[[Category: Zhou, M.]]
[[Category: Zhou, M.]]
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[[Category: beta subunit]]
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[[Category: Beta subunit]]
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[[Category: ion channel]]
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[[Category: Ion channel]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:37:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:11:26 2008''
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Revision as of 12:37, 2 May 2008

Image:1exb.gif

Template:STRUCTURE 1exb

STRUCTURE OF THE CYTOPLASMIC BETA SUBUNIT-T1 ASSEMBLY OF VOLTAGE-DEPENDENT K CHANNELS


Overview

The structure of the cytoplasmic assembly of voltage-dependent K+ channels was solved by x-ray crystallography at 2.1 angstrom resolution. The assembly includes the cytoplasmic (T1) domain of the integral membrane alpha subunit together with the oxidoreductase beta subunit in a fourfold symmetric T1(4)beta4 complex. An electrophysiological assay showed that this complex is oriented with four T1 domains facing the transmembrane pore and four beta subunits facing the cytoplasm. The transmembrane pore communicates with the cytoplasm through lateral, negatively charged openings above the T1(4)beta4 complex. The inactivation peptides of voltage-dependent K(+) channels reach their site of action by entering these openings.

About this Structure

1EXB is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels., Gulbis JM, Zhou M, Mann S, MacKinnon R, Science. 2000 Jul 7;289(5476):123-7. PMID:10884227 Page seeded by OCA on Fri May 2 15:37:51 2008

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