1bj8

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THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINIMIZED AVERAGE STRUCTURE

Overview

The transmembrane glycoprotein gp130 is the common signal transducing, receptor subunit of the interleukin-6-type cytokines. It is a member of, the cytokine-receptor superfamily predicted to consist of six domains in, its extracellular part. The second and third domain constitute the, cytokine-binding module defined by a set of four conserved cysteines and a, WSXWS motif, respectively. The three-dimensional structure of the, carboxy-terminal domain of this region was determined by multidimensional, NMR. The domain consists of seven beta-strands constituting a fibronectin, type III-like topology. The structure reveals that the WSDWS motif of, gp130 is part of an extended tryptophan/arginine zipper which modulates, the conformation of the CD loop.

About this Structure

1BJ8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The signal transducer gp130: solution structure of the carboxy-terminal domain of the cytokine receptor homology region., Kernebeck T, Pflanz S, Muller-Newen G, Kurapkat G, Scheek RM, Dijkstra K, Heinrich PC, Wollmer A, Grzesiek S, Grotzinger J, Protein Sci. 1999 Jan;8(1):5-12. PMID:10210178

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