1eyb

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[[Image:1eyb.jpg|left|200px]]
[[Image:1eyb.jpg|left|200px]]
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{{Structure
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|PDB= 1eyb |SIZE=350|CAPTION= <scene name='initialview01'>1eyb</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1eyb", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Homogentisate_1,2-dioxygenase Homogentisate 1,2-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.5 1.13.11.5] </span>
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{{STRUCTURE_1eyb| PDB=1eyb | SCENE= }}
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|RELATEDENTRY=[[1ey2|1EY2]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eyb OCA], [http://www.ebi.ac.uk/pdbsum/1eyb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1eyb RCSB]</span>
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'''CRYSTAL STRUCTURE OF APO HUMAN HOMOGENTISATE DIOXYGENASE'''
'''CRYSTAL STRUCTURE OF APO HUMAN HOMOGENTISATE DIOXYGENASE'''
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[[Category: Titus, G P.]]
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Revision as of 12:40, 2 May 2008

Image:1eyb.jpg

Template:STRUCTURE 1eyb

CRYSTAL STRUCTURE OF APO HUMAN HOMOGENTISATE DIOXYGENASE


Overview

Homogentisate dioxygenase (HGO) cleaves the aromatic ring during the metabolic degradation of Phe and Tyr. HGO deficiency causes alkaptonuria (AKU), the first human disease shown to be inherited as a recessive Mendelian trait. Crystal structures of apo-HGO and HGO containing an iron ion have been determined at 1.9 and 2.3 A resolution, respectively. The HGO protomer, which contains a 280-residue N-terminal domain and a 140-residue C-terminal domain, associates as a hexamer arranged as a dimer of trimers. The active site iron ion is coordinated near the interface between subunits in the HGO trimer by a Glu and two His side chains. HGO represents a new structural class of dioxygenases. The largest group of AKU associated missense mutations affect residues located in regions of contact between subunits.

About this Structure

1EYB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human homogentisate dioxygenase., Titus GP, Mueller HA, Burgner J, Rodriguez De Cordoba S, Penalva MA, Timm DE, Nat Struct Biol. 2000 Jul;7(7):542-6. PMID:10876237 Page seeded by OCA on Fri May 2 15:40:01 2008

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