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1g3i

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<StructureSection load='1g3i' size='340' side='right'caption='[[1g3i]], [[Resolution|resolution]] 3.41&Aring;' scene=''>
<StructureSection load='1g3i' size='340' side='right'caption='[[1g3i]], [[Resolution|resolution]] 3.41&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1g3i]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. The August 2006 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''AAA+ Proteases'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2006_8 10.2210/rcsb_pdb/mom_2006_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G3I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G3I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1g3i]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. The August 2006 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''AAA+ Proteases'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2006_8 10.2210/rcsb_pdb/mom_2006_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G3I FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g3k|1g3k]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1g3k|1g3k]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g3i OCA], [http://pdbe.org/1g3i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1g3i RCSB], [http://www.ebi.ac.uk/pdbsum/1g3i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1g3i ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g3i OCA], [https://pdbe.org/1g3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g3i RCSB], [https://www.ebi.ac.uk/pdbsum/1g3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g3i ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HSLU_HAEIN HSLU_HAEIN]] ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. [[http://www.uniprot.org/uniprot/HSLV_HAEIN HSLV_HAEIN]] Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.[HAMAP-Rule:MF_00248]
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[[https://www.uniprot.org/uniprot/HSLU_HAEIN HSLU_HAEIN]] ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. [[https://www.uniprot.org/uniprot/HSLV_HAEIN HSLV_HAEIN]] Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.[HAMAP-Rule:MF_00248]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 1g3i" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1g3i" style="background-color:#fffaf0;"></div>
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==See Also==
 
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*[[JSmol/Rotation Speeds|JSmol/Rotation Speeds]]
 
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*[[User:Eric Martz/JSmol Notes|User:Eric Martz/JSmol Notes]]
 
== References ==
== References ==
<references/>
<references/>

Revision as of 11:18, 28 July 2021

CRYSTAL STRUCTURE OF THE HSLUV PROTEASE-CHAPERONE COMPLEX

PDB ID 1g3i

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