1eyp

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[[Image:1eyp.jpg|left|200px]]
[[Image:1eyp.jpg|left|200px]]
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{{Structure
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|PDB= 1eyp |SIZE=350|CAPTION= <scene name='initialview01'>1eyp</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1eyp", creates the "Structure Box" on the page.
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|SITE=
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Chalcone_isomerase Chalcone isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.5.1.6 5.5.1.6] </span>
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{{STRUCTURE_1eyp| PDB=1eyp | SCENE= }}
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|RELATEDENTRY=[[1eyq|1EYQ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eyp OCA], [http://www.ebi.ac.uk/pdbsum/1eyp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1eyp RCSB]</span>
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'''CHALCONE ISOMERASE'''
'''CHALCONE ISOMERASE'''
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[[Category: Jez, J M.]]
[[Category: Jez, J M.]]
[[Category: Noel, J P.]]
[[Category: Noel, J P.]]
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[[Category: chalcone isomerase]]
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[[Category: Chalcone isomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:40:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:12:17 2008''
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Revision as of 12:40, 2 May 2008

Image:1eyp.jpg

Template:STRUCTURE 1eyp

CHALCONE ISOMERASE


Overview

Chalcone isomerase (CHI) catalyzes the intramolecular cyclization of chalcone synthesized by chalcone synthase (CHS) into (2S)-naringenin, an essential compound in the biosynthesis of anthocyanin pigments, inducers of Rhizobium nodulation genes, and antimicrobial phytoalexins. The 1.85 A resolution crystal structure of alfalfa CHI in complex with (2S)-naringenin reveals a novel open-faced beta-sandwich fold. Currently, proteins with homologous primary sequences are found only in higher plants. The topology of the active site cleft defines the stereochemistry of the cyclization reaction. The structure and mutational analysis suggest a mechanism in which shape complementarity of the binding cleft locks the substrate into a constrained conformation that allows the reaction to proceed with a second-order rate constant approaching the diffusion controlled limit. This structure raises questions about the evolutionary history of this structurally unique plant enzyme.

About this Structure

1EYP is a Single protein structure of sequence from Medicago sativa. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of the evolutionarily unique plant enzyme chalcone isomerase., Jez JM, Bowman ME, Dixon RA, Noel JP, Nat Struct Biol. 2000 Sep;7(9):786-91. PMID:10966651 Page seeded by OCA on Fri May 2 15:40:46 2008

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