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1h0l

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Revision as of 11:30, 28 July 2021

HUMAN PRION PROTEIN 121-230 M166C/E221C

Structural highlights

1h0l is a 1 chain structure with sequence from Human. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	1fkc, 1fo7, 1i4m, 1qlx, 1qlz, 1qm0, 1qm1, 1qm2, 1qm3
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The nuclear magnetic resonance structure of the globular domain with residues 121-230 of a variant human prion protein with two disulfide bonds, hPrP(M166C/E221C), shows the same global fold as wild-type hPrP(121-230). It contains three alpha-helices of residues 144-154, 173-194 and 200-228, an anti-parallel beta-sheet of residues 128-131 and 161-164, and the disulfides Cys166-Cys221 and Cys179-Cys214. The engineered extra disulfide bond in the presumed "protein X"-binding site is accommodated with slight, strictly localized conformational changes. High compatibility of hPrP with insertion of a second disulfide bridge in the protein X epitope was further substantiated by model calculations with additional variant structures. The ease with which the hPrP structure can accommodate a variety of locations for a second disulfide bond within the presumed protein X-binding epitope suggests a functional role for the extensive perturbation by a natural second disulfide bond of the corresponding region in the human doppel protein.

NMR structure of a variant human prion protein with two disulfide bridges.,Zahn R, Guntert P, von Schroetter C, Wuthrich K J Mol Biol. 2003 Feb 7;326(1):225-34. PMID:12547204^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Zahn R, Guntert P, von Schroetter C, Wuthrich K. NMR structure of a variant human prion protein with two disulfide bridges. J Mol Biol. 2003 Feb 7;326(1):225-34. PMID:12547204

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1h0l"

@@ Line 3: / Line 3: @@
 <StructureSection load='1h0l' size='340' side='right'caption='[[1h0l]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1h0l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H0L FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1h0l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H0L FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1fkc|1fkc]], [[1fo7|1fo7]], [[1i4m|1i4m]], [[1qlx|1qlx]], [[1qlz|1qlz]], [[1qm0|1qm0]], [[1qm1|1qm1]], [[1qm2|1qm2]], [[1qm3|1qm3]]</td></tr>
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1fkc|1fkc]], [[1fo7|1fo7]], [[1i4m|1i4m]], [[1qlx|1qlx]], [[1qlz|1qlz]], [[1qm0|1qm0]], [[1qm1|1qm1]], [[1qm2|1qm2]], [[1qm3|1qm3]]</div></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0l OCA], [http://pdbe.org/1h0l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h0l RCSB], [http://www.ebi.ac.uk/pdbsum/1h0l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1h0l ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0l OCA], [https://pdbe.org/1h0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h0l RCSB], [https://www.ebi.ac.uk/pdbsum/1h0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h0l ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==
@@ Line 28: / Line 28: @@
 ==See Also==
-*[[Doppel|Doppel]]
+*[[Prion 3D structures|Prion 3D structures]]
-*[[Prion|Prion]]
 == References ==
 <references/>

1h0l

From Proteopedia

Revision as of 11:30, 28 July 2021

HUMAN PRION PROTEIN 121-230 M166C/E221C

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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