1eyv

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[[Image:1eyv.gif|left|200px]]
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{{Structure
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|PDB= 1eyv |SIZE=350|CAPTION= <scene name='initialview01'>1eyv</scene>, resolution 1.6&Aring;
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The line below this paragraph, containing "STRUCTURE_1eyv", creates the "Structure Box" on the page.
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00619 Terminator_NusB]</span>
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{{STRUCTURE_1eyv| PDB=1eyv | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eyv OCA], [http://www.ebi.ac.uk/pdbsum/1eyv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1eyv RCSB]</span>
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'''THE CRYSTAL STRUCTURE OF NUSB FROM MYCOBACTERIUM TUBERCULOSIS'''
'''THE CRYSTAL STRUCTURE OF NUSB FROM MYCOBACTERIUM TUBERCULOSIS'''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:41:07 2008''
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Revision as of 12:41, 2 May 2008

Image:1eyv.gif

Template:STRUCTURE 1eyv

THE CRYSTAL STRUCTURE OF NUSB FROM MYCOBACTERIUM TUBERCULOSIS


Overview

Both prokaryotes and eukaryotes regulate transcription through mechanisms that suppress termination signals. An antitermination mechanism was first characterized in bacteriophage lambda. Bacteria have analogous machinery that regulates ribosomal RNA transcription and employs host factors, called the N-utilizing (where N stands for the phage lambda N protein) substances (Nus), NusA, NusB, NusE and NusG. Here we report the crystal structure of NusB from Mycobacterium tuberculosis, the bacterium that causes tuberculosis in humans. This molecule shares a similar tertiary structure with the related Escherichia coli protein but adopts a different quaternary organization. We show that, unlike the E. coli homolog, M. tuberculosis NusB is dimeric both in solution and in the crystal. These data help provide a framework for understanding the structural and biological function of NusB in the prokaryotic transcriptional antitermination complex.

About this Structure

1EYV is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

The crystal structure of NusB from Mycobacterium tuberculosis., Gopal B, Haire LF, Cox RA, Jo Colston M, Major S, Brannigan JA, Smerdon SJ, Dodson G, Nat Struct Biol. 2000 Jun;7(6):475-8. PMID:10881194 Page seeded by OCA on Fri May 2 15:41:07 2008

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