6z98
From Proteopedia
(Difference between revisions)
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==NMR solution structure of the peach allergen Pru p 1.0101== | ==NMR solution structure of the peach allergen Pru p 1.0101== | ||
| - | <StructureSection load='6z98' size='340' side='right'caption='[[6z98]]' scene=''> | + | <StructureSection load='6z98' size='340' side='right'caption='[[6z98]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[6z98]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Amygdalus_persica Amygdalus persica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z98 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z98 OCA], [https://pdbe.org/6z98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z98 RCSB], [https://www.ebi.ac.uk/pdbsum/6z98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z98 ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ypr-10, PR10, PRUPE_1G128700, PRUPE_ppa012651mg ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3760 Amygdalus persica])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z98 OCA], [https://pdbe.org/6z98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z98 RCSB], [https://www.ebi.ac.uk/pdbsum/6z98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z98 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Peach (Prunus persica) is among the fruits most frequently reported to cause food allergies. Allergic reactions commonly result from previous sensitization to the birch pollen allergen Bet v 1, followed by immunological cross-reactivity of IgE antibodies to structurally related proteins in peach. In this study, we present the three-dimensional NMR solution structure of the cross-reactive peach allergen Pru p 1 (isoform Pru p 1.0101). This 17.5 kDa protein adopts the canonical Bet v 1 fold, composed of a seven-stranded beta-sheet and three alpha-helices enclosing an internal cavity. In Pru p 1, the inner surface of the cavity contains an array of hydroxyl-bearing amino acids surrounded by a hydrophobic patch, constituting a docking site for amphiphilic molecules. NMR-guided docking of the cytokinin molecule zeatin to the internal cavity of Pru p 1 provides a structure-based rationale for the effect that zeatin binding has on the protein's RNase activity. | ||
| + | |||
| + | Structure and Zeatin Binding of the Peach Allergen Pru p 1.,Eidelpes R, Hofer F, Rock M, Fuhrer S, Kamenik AS, Liedl KR, Tollinger M J Agric Food Chem. 2021 Jul 28;69(29):8120-8129. doi: 10.1021/acs.jafc.1c01876., Epub 2021 Jul 14. PMID:34260238<ref>PMID:34260238</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6z98" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Amygdalus persica]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Eidelpes R]] | + | [[Category: Eidelpes, R]] |
| - | [[Category: Fuehrer S]] | + | [[Category: Fuehrer, S]] |
| - | [[Category: Hofer F]] | + | [[Category: Hofer, F]] |
| - | [[Category: Kamenik | + | [[Category: Kamenik, A S]] |
| - | [[Category: Liedl | + | [[Category: Liedl, K R]] |
| - | [[Category: Tollinger M]] | + | [[Category: Tollinger, M]] |
| + | [[Category: Allergen]] | ||
| + | [[Category: Cross-allergy]] | ||
| + | [[Category: Pathogenesis related protein]] | ||
| + | [[Category: Peach pru p 1 food allergen]] | ||
Current revision
NMR solution structure of the peach allergen Pru p 1.0101
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