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1hxc
From Proteopedia
(Difference between revisions)
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<StructureSection load='1hxc' size='340' side='right'caption='[[1hxc]], [[Resolution|resolution]] 2.25Å' scene=''> | <StructureSection load='1hxc' size='340' side='right'caption='[[1hxc]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1hxc]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1hxc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/American_tobacco American tobacco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HXC FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FHP:1-HYDROXY-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENE+PHOSPHONIC+ACID'>FHP</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FHP:1-HYDROXY-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENE+PHOSPHONIC+ACID'>FHP</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5eas|5eas]], [[5eat|5eat]], [[1hx9|1hx9]], [[1hxa|1hxa]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[5eas|5eas]], [[5eat|5eat]], [[1hx9|1hx9]], [[1hxa|1hxa]]</div></td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aristolochene_synthase Aristolochene synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.9 4.2.3.9] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hxc OCA], [https://pdbe.org/1hxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hxc RCSB], [https://www.ebi.ac.uk/pdbsum/1hxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hxc ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/5EAS_TOBAC 5EAS_TOBAC]] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 10:54, 4 August 2021
CRYSTAL STRUCTURE OF TEAS C440W
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