1i1j

From Proteopedia

(Difference between revisions)

Revision as of 10:55, 4 August 2021

STRUCTURE OF MELANOMA INHIBITORY ACTIVITY PROTEIN: A MEMBER OF A NEW FAMILY OF SECRETED PROTEINS

Structural highlights

1i1j is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[MIA_HUMAN] Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Melanoma inhibitory activity (MIA) is a 12-kDa protein that is secreted from both chondrocytes and malignant melanoma cells. MIA has been reported to have effects on cell growth and adhesion, and it may play a role in melanoma metastasis and cartilage development. We report the 1.4-A crystal structure of human MIA, which consists of an Src homology 3 (SH3)-like domain with N- and C-terminal extensions of about 20 aa. each. The N- and C-terminal extensions add additional structural elements to the SH3 domain, forming a previously undescribed fold. MIA is a representative of a recently identified family of proteins and is the first structure of a secreted protein with an SH3 subdomain. The structure also suggests a likely protein interaction site and suggests that, unlike conventional SH3 domains, MIA does not recognize polyproline helices.

Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins.,Lougheed JC, Holton JM, Alber T, Bazan JF, Handel TM Proc Natl Acad Sci U S A. 2001 May 8;98(10):5515-20. Epub 2001 May 1. PMID:11331761^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Lougheed JC, Holton JM, Alber T, Bazan JF, Handel TM. Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins. Proc Natl Acad Sci U S A. 2001 May 8;98(10):5515-20. Epub 2001 May 1. PMID:11331761 doi:10.1073/pnas.091601698

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1i1j"

@@ Line 3: / Line 3: @@
 <StructureSection load='1i1j' size='340' side='right'caption='[[1i1j]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1i1j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I1J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I1J FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1i1j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I1J FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i1j OCA], [http://pdbe.org/1i1j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1i1j RCSB], [http://www.ebi.ac.uk/pdbsum/1i1j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1i1j ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i1j OCA], [https://pdbe.org/1i1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i1j RCSB], [https://www.ebi.ac.uk/pdbsum/1i1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i1j ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/MIA_HUMAN MIA_HUMAN]] Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.
+[[https://www.uniprot.org/uniprot/MIA_HUMAN MIA_HUMAN]] Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]

1i1j

From Proteopedia

Revision as of 10:55, 4 August 2021

STRUCTURE OF MELANOMA INHIBITORY ACTIVITY PROTEIN: A MEMBER OF A NEW FAMILY OF SECRETED PROTEINS

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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