1f05

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[[Image:1f05.gif|left|200px]]
[[Image:1f05.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1f05 |SIZE=350|CAPTION= <scene name='initialview01'>1f05</scene>, resolution 2.45&Aring;
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The line below this paragraph, containing "STRUCTURE_1f05", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transaldolase Transaldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.2.1.2 2.2.1.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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{{STRUCTURE_1f05| PDB=1f05 | SCENE= }}
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|RELATEDENTRY=[[1onr|1ONR]], [[1ucw|1UCW]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f05 OCA], [http://www.ebi.ac.uk/pdbsum/1f05 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1f05 RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF HUMAN TRANSALDOLASE'''
'''CRYSTAL STRUCTURE OF HUMAN TRANSALDOLASE'''
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[[Category: Schneider, G.]]
[[Category: Schneider, G.]]
[[Category: Thorell, S.]]
[[Category: Thorell, S.]]
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[[Category: alpha-beta barrel]]
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[[Category: Alpha-beta barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:44:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:13:11 2008''
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Revision as of 12:44, 2 May 2008

Image:1f05.gif

Template:STRUCTURE 1f05

CRYSTAL STRUCTURE OF HUMAN TRANSALDOLASE


Overview

The crystal structure of human transaldolase has been determined to 2.45 A resolution. The enzyme folds into an alpha/beta barrel structure and is thus similar in structure to other class I aldolases. Structure-based sequence alignment of available sequences of the transaldolase subfamily reveals that eight active site residues are invariant in the whole subfamily. Other invariant residues are mainly involved in the formation of the hydrophobic core of the enzyme. Noteworthy is a hydrophobic cluster consisting of five invariant residues. Human transaldolase has been implicated as an autoantigen in multiple sclerosis and four immunodominant peptide segments are located at the surface of the enzyme, accessible to autoantibodies.

About this Structure

1F05 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The three-dimensional structure of human transaldolase., Thorell S, Gergely P Jr, Banki K, Perl A, Schneider G, FEBS Lett. 2000 Jun 23;475(3):205-8. PMID:10869557 Page seeded by OCA on Fri May 2 15:44:00 2008

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