1f0j

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[[Image:1f0j.gif|left|200px]]
[[Image:1f0j.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1f0j |SIZE=350|CAPTION= <scene name='initialview01'>1f0j</scene>, resolution 1.77&Aring;
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The line below this paragraph, containing "STRUCTURE_1f0j", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ARS:ARSENIC'>ARS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1f0j| PDB=1f0j | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f0j OCA], [http://www.ebi.ac.uk/pdbsum/1f0j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1f0j RCSB]</span>
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}}
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'''CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B'''
'''CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B'''
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[[Category: Xu, R X.]]
[[Category: Xu, R X.]]
[[Category: Zhao, Y.]]
[[Category: Zhao, Y.]]
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[[Category: pde phosphodiesterase]]
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[[Category: Pde phosphodiesterase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:44:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:13:22 2008''
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Revision as of 12:44, 2 May 2008

Image:1f0j.gif

Template:STRUCTURE 1f0j

CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B


Overview

Cyclic nucleotides are second messengers that are essential in vision, muscle contraction, neurotransmission, exocytosis, cell growth, and differentiation. These molecules are degraded by a family of enzymes known as phosphodiesterases, which serve a critical function by regulating the intracellular concentration of cyclic nucleotides. We have determined the three-dimensional structure of the catalytic domain of phosphodiesterase 4B2B to 1.77 angstrom resolution. The active site has been identified and contains a cluster of two metal atoms. The structure suggests the mechanism of action and basis for specificity and will provide a framework for structure-assisted drug design for members of the phosphodiesterase family.

About this Structure

1F0J is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity., Xu RX, Hassell AM, Vanderwall D, Lambert MH, Holmes WD, Luther MA, Rocque WJ, Milburn MV, Zhao Y, Ke H, Nolte RT, Science. 2000 Jun 9;288(5472):1822-5. PMID:10846163 Page seeded by OCA on Fri May 2 15:44:44 2008

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OCA

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