1k12

From Proteopedia

(Difference between revisions)

Revision as of 06:47, 11 August 2021

Fucose Binding lectin

Structural highlights

1k12 is a 1 chain structure with sequence from Anguilla anguilla. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[FUCL_ANGAN] Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Anguilla anguilla agglutinin (AAA), a fucolectin found in the serum of European eel, participates in the recognition of bacterial liposaccharides by the animal innate immunity system. Because AAA specifically recognizes fucosylated terminals of H and Lewis (a) blood groups, it has been used extensively as a reagent in blood typing and histochemistry. AAA contains a newly discovered carbohydrate recognition domain present in proteins of organisms ranging from bacteria to vertebrates. The crystal structure of the complex of AAA with alpha-L-fucose characterizes the novel fold of this entire lectin family, identifying the residues that provide the structural determinants of oligosaccharide specificity. Modification of these residues explains how the different isoforms in serum can provide a diverse pathogen-specific recognition.

A novel fucose recognition fold involved in innate immunity.,Bianchet MA, Odom EW, Vasta GR, Amzel LM Nat Struct Biol. 2002 Aug;9(8):628-34. PMID:12091873^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Wu AM, Wu JH, Singh T, Liu JH, Herp A. Lectinochemical studies on the affinity of Anguilla anguilla agglutinin for mammalian glycotopes. Life Sci. 2004 Jul 16;75(9):1085-103. PMID:15207656 doi:http://dx.doi.org/10.1016/j.lfs.2004.02.016
↑ Bianchet MA, Odom EW, Vasta GR, Amzel LM. A novel fucose recognition fold involved in innate immunity. Nat Struct Biol. 2002 Aug;9(8):628-34. PMID:12091873 doi:10.1038/nsb817
↑ Bianchet MA, Odom EW, Vasta GR, Amzel LM. A novel fucose recognition fold involved in innate immunity. Nat Struct Biol. 2002 Aug;9(8):628-34. PMID:12091873 doi:10.1038/nsb817

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1k12"

@@ Line 3: / Line 3: @@
 <StructureSection load='1k12' size='340' side='right'caption='[[1k12]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1k12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anguilla_anguilla Anguilla anguilla]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K12 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1k12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anguilla_anguilla Anguilla anguilla]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K12 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k12 OCA], [http://pdbe.org/1k12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1k12 RCSB], [http://www.ebi.ac.uk/pdbsum/1k12 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1k12 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k12 OCA], [https://pdbe.org/1k12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k12 RCSB], [https://www.ebi.ac.uk/pdbsum/1k12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k12 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/FUCL_ANGAN FUCL_ANGAN]] Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.<ref>PMID:15207656</ref> <ref>PMID:12091873</ref>
+[[https://www.uniprot.org/uniprot/FUCL_ANGAN FUCL_ANGAN]] Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.<ref>PMID:15207656</ref> <ref>PMID:12091873</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]

1k12

From Proteopedia

Revision as of 06:47, 11 August 2021

Fucose Binding lectin

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox