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1f2q

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[[Image:1f2q.jpg|left|200px]]
[[Image:1f2q.jpg|left|200px]]
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{{Structure
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|PDB= 1f2q |SIZE=350|CAPTION= <scene name='initialview01'>1f2q</scene>, resolution 2.40&Aring;
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The line below this paragraph, containing "STRUCTURE_1f2q", creates the "Structure Box" on the page.
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{{STRUCTURE_1f2q| PDB=1f2q | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f2q OCA], [http://www.ebi.ac.uk/pdbsum/1f2q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1f2q RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THE HUMAN HIGH-AFFINITY IGE RECEPTOR'''
'''CRYSTAL STRUCTURE OF THE HUMAN HIGH-AFFINITY IGE RECEPTOR'''
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[[Category: Jardetzky, T S.]]
[[Category: Jardetzky, T S.]]
[[Category: Kinet, J P.]]
[[Category: Kinet, J P.]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: ige-binding protein]]
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[[Category: Ige-binding protein]]
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[[Category: immunoglobulin fold]]
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[[Category: Immunoglobulin fold]]
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[[Category: receptor]]
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[[Category: Receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:49:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:14:34 2008''
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Revision as of 12:49, 2 May 2008

Image:1f2q.jpg

Template:STRUCTURE 1f2q

CRYSTAL STRUCTURE OF THE HUMAN HIGH-AFFINITY IGE RECEPTOR


Overview

Allergic responses result from the activation of mast cells by the human high-affinity IgE receptor. IgE-mediated allergic reactions may develop to a variety of environmental compounds, but the initiation of a response requires the binding of IgE to its high-affinity receptor. We have solved the X-ray crystal structure of the antibody-binding domains of the human IgE receptor at 2.4 A resolution. The structure reveals a highly bent arrangement of immunoglobulin domains that form an extended convex surface of interaction with IgE. A prominent loop that confers specificity for IgE molecules extends from the receptor surface near an unusual arrangement of four exposed tryptophans. The crystal structure of the IgE receptor provides a foundation for the development of new therapeutic approaches to allergy treatment.

About this Structure

1F2Q is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human high-affinity IgE receptor., Garman SC, Kinet JP, Jardetzky TS, Cell. 1998 Dec 23;95(7):951-61. PMID:9875849 Page seeded by OCA on Fri May 2 15:49:13 2008

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