6nt4

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<SX load='6nt4' size='340' side='right' viewer='molstar' caption='[[6nt4]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<SX load='6nt4' size='340' side='right' viewer='molstar' caption='[[6nt4]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6nt4]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/American_cockroach American cockroach] and [http://en.wikipedia.org/wiki/Androctonus_australis Androctonus australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NT4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6NT4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6nt4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/American_cockroach American cockroach] and [https://en.wikipedia.org/wiki/Androctonus_australis Androctonus australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NT4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=L0A:Digitonin'>L0A</scene>, <scene name='pdbligand=LHG:1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE'>LHG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=76F:(7E,21R,24S)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl+(9Z,12E)-octadeca-9,12-dienoate'>76F</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=L0A:Digitonin'>L0A</scene>, <scene name='pdbligand=LHG:1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE'>LHG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6nt3|6nt3]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6nt3|6nt3]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SCN9A, NENA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6978 American cockroach])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SCN9A, NENA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6978 American cockroach])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6nt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nt4 OCA], [http://pdbe.org/6nt4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nt4 RCSB], [http://www.ebi.ac.uk/pdbsum/6nt4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nt4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nt4 OCA], [https://pdbe.org/6nt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nt4 RCSB], [https://www.ebi.ac.uk/pdbsum/6nt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nt4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SCNA1_PERAM SCNA1_PERAM]] Mediates the voltage-dependent sodium ion permeability of excitable membranes.[RuleBase:RU361132]<ref>PMID:28183995</ref> [[http://www.uniprot.org/uniprot/SCX2_ANDAU SCX2_ANDAU]] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against mammals.
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[[https://www.uniprot.org/uniprot/SCNA1_PERAM SCNA1_PERAM]] Mediates the voltage-dependent sodium ion permeability of excitable membranes.[RuleBase:RU361132]<ref>PMID:28183995</ref> [[https://www.uniprot.org/uniprot/SCX2_ANDAU SCX2_ANDAU]] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against mammals.
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 06:13, 18 August 2021

Cryo-EM structure of a human-cockroach hybrid Nav channel bound to alpha-scorpion toxin AaH2.

6nt4, resolution 3.50Å

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OCA

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