6xcz
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Porcine pepsin in complex with saquinavir== | ==Porcine pepsin in complex with saquinavir== | ||
| - | <StructureSection load='6xcz' size='340' side='right'caption='[[6xcz]]' scene=''> | + | <StructureSection load='6xcz' size='340' side='right'caption='[[6xcz]], [[Resolution|resolution]] 1.89Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XCZ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6xcz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XCZ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xcz OCA], [https://pdbe.org/6xcz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xcz RCSB], [https://www.ebi.ac.uk/pdbsum/6xcz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xcz ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ROC:(2S)-N-[(2S,3R)-4-[(2S,3S,4AS,8AS)-3-(TERT-BUTYLCARBAMOYL)-3,4,4A,5,6,7,8,8A-OCTAHYDRO-1H-ISOQUINOLIN-2-YL]-3-HYDROXY-1-PHENYL-BUTAN-2-YL]-2-(QUINOLIN-2-YLCARBONYLAMINO)BUTANEDIAMIDE'>ROC</scene></td></tr> |
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pepsin_A Pepsin A], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.1 3.4.23.1] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xcz OCA], [https://pdbe.org/6xcz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xcz RCSB], [https://www.ebi.ac.uk/pdbsum/6xcz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xcz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/PEPA_PIG PEPA_PIG]] Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Silvaggi | + | [[Category: Pepsin A]] |
| - | [[Category: Vuksanovic N]] | + | [[Category: Sus scrofa]] |
| + | [[Category: Silvaggi, N R]] | ||
| + | [[Category: Vuksanovic, N]] | ||
| + | [[Category: Hiv]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Hydrolase-inhibitor complex]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Pepsin]] | ||
| + | [[Category: Protease]] | ||
Revision as of 06:14, 18 August 2021
Porcine pepsin in complex with saquinavir
| |||||||||||
